| Excess ventilation during exercise and prognosis in chronic heart failure. | |
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MedLine Citation:
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PMID: 21257789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Excess ventilation during exercise with accompanying dyspnea is characteristic of chronic heart failure (CHF), and these patients often exhibit increased Ve relative to the Vco(2) compared with normal subjects. This can be measured in several ways, including using such variables as the slope of Ve versus Vco(2), the lowest ratio of Ve/Vco(2), and the ratio of Ve/Vco(2) at the lactic acidosis threshold or peak exercise. There is now considerable evidence that the degree of excess ventilation during exercise in patients with CHF is a robust predictor of outcome and identifies higher-risk patients requiring aggressive treatment, including heart transplantation. The mechanism of excess ventilation in patients with CHF during exercise is not completely understood. It may be related to enhanced output of chemoreceptors or peripheral muscle ergoreceptors, increased dead space/Vt ratio due to increased contribution of high ventilation-perfusion lung regions or rapid shallow breathing caused by earlier onset of lactic acidosis, or likely resulting from a combination of these causes. |
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Authors:
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Darryl Y Sue |
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Publication Detail:
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Type: Journal Article; Review Date: 2011-01-21 |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 183 ISSN: 1535-4970 ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-20 Completed Date: 2011-07-26 Revised Date: 2012-02-17 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 1302-10 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA 90509-2910, USA. dsue@ucla.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis, Respiratory
/
complications,
diagnosis,
physiopathology Blood Gas Analysis Carbon Dioxide / metabolism Chronic Disease Exercise* Exercise Test / methods* Exercise Tolerance Heart Failure / complications, diagnosis*, physiopathology Humans Oxygen Consumption Predictive Value of Tests Prognosis Pulmonary Ventilation* Respiratory Dead Space |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
| Comments/Corrections | |
Comment In:
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Am J Respir Crit Care Med. 2012 Jan 15;185(2):227; author reply 227-8
[PMID:
22246706
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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