Document Detail


Excess Sudden Cardiac Deaths after Short-Term Clarithromycin Administration in the CLARICOR Trial: Why Is This So, and Why Are Statins Protective?
MedLine Citation:
PMID:  21447948     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives: To elucidate potential mechanisms for the clarithromycin-induced excess mortality observed in the CLARICOR trial during 2.6 year follow-up of patients with stable coronary artery disease. Methods: Cox analyses using out-of-hospital death as a proxy for sudden death compared to in-hospital (nonsudden) death. Result: In 100 of 189 (53%) cardiovascular (CV) deaths in which it was possible to examine the question, there was a strong association between place of death and the classification of CV death as sudden or not-sudden. The excess mortality in the clarithromycin group was confined to sudden CV death in patients not on statins at trial entry (HR: 2.61, 95% CI: 1.69-4.05, p < 0.0005). Other categories of deaths showed no marked drug-placebo difference. Conclusions: Short-term clarithromycin administration was significantly associated with increased risk of sudden CV death in stable coronary heart disease patients not using statins.
Authors:
Per Winkel; Jørgen Hilden; Jørgen Fischer Hansen; Per Hildebrandt; Jens Kastrup; Hans Jørn Kolmos; Erik Kjøller; Christian M Jespersen; Christian Gluud; Gorm Boje Jensen
Related Documents :
10773058 - Randomized trial assessing the feasibility and safety of biologic parents as rbc donors...
11309178 - Antenatal ultrasonographic features of fetal giant hemangiolymphangioma.
9128818 - Effect of blood transfusion on apnoea, bradycardia and hypoxaemia in preterm infants.
1957818 - Essential fatty acid status and fluidity of plasma phospholipids in cystic fibrosis inf...
22020148 - Detection of torque teno sus virus types 1 and 2 by nested polymerase chain reaction in...
24886238 - An equivalence evaluation of a nurse-moderated group-based internet support program for...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-26
Journal Detail:
Title:  Cardiology     Volume:  118     ISSN:  1421-9751     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  63-67     Citation Subset:  -    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
Rigshospitalet, Copenhagen University Hospital and Institute of Preventive Medicine, The Copenhagen Trial Unit, Center for Clinical Intervention Research, Copenhagen, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Irinotecan-cetuximab-bevacizumab as a salvage treatment in heavily pretreated metastatic colorectal ...
Next Document:  The Effect of Hyperbaric Oxygenation on Postradiation Xerostomia and Saliva in Patients with Head an...