Document Detail


Exceptional CO(2) Tolerance in White Sturgeon (Acipenser transmontanus) Is Associated with Protection of Maximum Cardiac Performance during Hypercapnia In Situ.
MedLine Citation:
PMID:  21527814     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Abstract White sturgeon rank among the most CO(2)-tolerant fish species examined to date. We investigated whether this exceptional CO(2) tolerance extended to the heart, an organ generally viewed as acidosis intolerant. Maximum cardiac output (Q(max)) and maximum cardiac power output (PO(max)) were assessed using a working, perfused, in situ heart preparation. Exposure to a Pco(2) of 3 kPa for 20 min had no significant effect on maximum cardiac performance, while exposure to 6-kPa Pco(2) reduced heart rate, Q(max), PO(max), and rate of ventricular force generation (F(O)) by 23%, 28%, 26%, and 18%, respectively; however, full recovery was observed in all these parameters upon return to control conditions. These modest impairments during exposure to 6-kPa Pco(2) were associated with partially compensated intracellular ventricular acidosis. Maximum adrenergic stimulation (500 nmol L(-1) adrenaline) during 6-kPa Pco(2) protected maximum cardiac performance via increased inotropy (force of contraction) without affecting heart rate. Exposure to higher CO(2) levels associated with morbidity in vivo (i.e., 8-kPa Pco(2)) induced arrhythmia and a reduction in stroke volume during power assessment. Clearly, white sturgeon hearts are able to increase cardiac performance during severe hypercapnia that is lethal to other fishes. Future work focusing on atypical aspects of sturgeon cardiac function, including the lack of chronotropic response to adrenergic stimulation during hypercapnia, is warranted.
Authors:
Daniel W Baker; Linda M Hanson; Anthony P Farrell; Colin J Brauner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiological and biochemical zoology : PBZ     Volume:  84     ISSN:  1537-5293     ISO Abbreviation:  Physiol. Biochem. Zool.     Publication Date:    2011 May-Jun
Date Detail:
Created Date:  2011-04-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883369     Medline TA:  Physiol Biochem Zool     Country:  United States    
Other Details:
Languages:  eng     Pagination:  239-48     Citation Subset:  IM    
Affiliation:
School of Biological Science, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; 2Faculty of Land and Food Systems, University of British Columbia, 2357 Main Mall, Vancouver, British Columbia V6T 1Z4, Canada; 3Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, British Columbia V6T 1Z4, Canada.
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