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Excellent tolerance to cilnidipine in hypertensives with amlodipine - induced edema.
MedLine Citation:
PMID:  23378956     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Ankle edema is a common adverse effect of amlodipine, an L-type calcium channel blocker (CCB). Cilnidipine is a newer L/N-type CCB, approved for treatment of essential hypertension.
AIM: This study was designed to determine whether cilnidipine can produce resolution of amlodipine-induced edema while maintaining adequate control of hypertension.
MATERIALS AND METHODS: A prospective study was performed on 27 patients with essential hypertension with amlodipine-induced edema. Concomitant nephropathy, cardiac failure, hepatic cirrhosis, or other causes of edema, and secondary hypertension were excluded by appropriate tests. Amlodipine therapy was substituted in all the cases with an efficacy-equivalent dose of cilnidipine. Clinical assessment of ankle edema and measurement of bilateral ankle circumference, body weight, blood pressure, and pulse rate were performed at onset of the study and after 4 weeks of cilnidipine therapy.
RESULTS: At completion of the study, edema had resolved in all the patients. There was a significant decrease in bilateral ankle circumference and body weight (P < 0.001). There was no significant change in mean arterial blood pressure and pulse rate.
CONCLUSIONS: Therapy with cilnidipine resulted in complete resolution of amlodipine-induced edema in all the cases without significant worsening of hypertension or tachycardia. Cilnidipine is an acceptable alternative antihypertensive for patients with amlodipine-induced edema.
Authors:
Ranjan Shetty; G Vivek; Kushal Naha; Anil Tumkur; Abhinav Raj; K L Bairy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  North American journal of medical sciences     Volume:  5     ISSN:  2250-1541     ISO Abbreviation:  N Am J Med Sci     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-02-05     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101521411     Medline TA:  N Am J Med Sci     Country:  India    
Other Details:
Languages:  eng     Pagination:  47-50     Citation Subset:  -    
Affiliation:
Department of Cardiology, Kasturba Medical College, Manipal, Karnataka, India.
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