| Excellent tolerance to cilnidipine in hypertensives with amlodipine - induced edema. | |
| | |
MedLine Citation:
|
PMID: 23378956 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Ankle edema is a common adverse effect of amlodipine, an L-type calcium channel blocker (CCB). Cilnidipine is a newer L/N-type CCB, approved for treatment of essential hypertension. AIM: This study was designed to determine whether cilnidipine can produce resolution of amlodipine-induced edema while maintaining adequate control of hypertension. MATERIALS AND METHODS: A prospective study was performed on 27 patients with essential hypertension with amlodipine-induced edema. Concomitant nephropathy, cardiac failure, hepatic cirrhosis, or other causes of edema, and secondary hypertension were excluded by appropriate tests. Amlodipine therapy was substituted in all the cases with an efficacy-equivalent dose of cilnidipine. Clinical assessment of ankle edema and measurement of bilateral ankle circumference, body weight, blood pressure, and pulse rate were performed at onset of the study and after 4 weeks of cilnidipine therapy. RESULTS: At completion of the study, edema had resolved in all the patients. There was a significant decrease in bilateral ankle circumference and body weight (P < 0.001). There was no significant change in mean arterial blood pressure and pulse rate. CONCLUSIONS: Therapy with cilnidipine resulted in complete resolution of amlodipine-induced edema in all the cases without significant worsening of hypertension or tachycardia. Cilnidipine is an acceptable alternative antihypertensive for patients with amlodipine-induced edema. |
| | |
Authors:
|
Ranjan Shetty; G Vivek; Kushal Naha; Anil Tumkur; Abhinav Raj; K L Bairy |
Related Documents
:
|
9684766 - Intraoral pressure and velopharyngeal function. 6471386 - Frequency analysis of the first and second heart sounds of humans. 23498356 - The effects of different shoes on plantar forces in irish dance. 15490306 - Effects of sounds generated by a dental turbine and a stream on regional cerebral blood... 10874346 - Recovery from stress in two different postures and in shavasana--a yogic relaxation pos... 926316 - Peri-ureteric collateral vessels in rabbits with experimental renal hypertension. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: North American journal of medical sciences Volume: 5 ISSN: 2250-1541 ISO Abbreviation: N Am J Med Sci Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-02-04 Completed Date: 2013-02-05 Revised Date: 2013-05-30 |
Medline Journal Info:
|
Nlm Unique ID: 101521411 Medline TA: N Am J Med Sci Country: India |
Other Details:
|
Languages: eng Pagination: 47-50 Citation Subset: - |
Affiliation:
|
Department of Cardiology, Kasturba Medical College, Manipal, Karnataka, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Serum Cholesterol and Ceruloplasmin Levels in Second Trimester can Predict Development of Pre-eclamp...
Next Document: Evaluation of Total Antioxidant Capacity of Saliva in Type 2 Diabetic Patients with and without Peri...