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Excellent outcomes of children with CML treated with imatinib mesylate compared to that in pre-imatinib era.
MedLine Citation:
PMID:  21234820     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Allogeneic hematopoietic stem cell transplantation (HSCT) and tyrosine kinase inhibitor have revolutionized the treatment of patients with chronic myeloid leukemia (CML). In this study, the clinical impact of HSCT and imatinib mesylate (IM) was retrospectively analyzed in 28 children with CML treated in our institutes from 1984 to 2008. Twelve patients were given oral IM. At 36 months after initiation of IM therapy, the complete cytogenetic response rate was 90.9%, and the major molecular response rate was 36.4%. Sixteen children received allogeneic HSCT without administration of IM. The stage of disease at transplantation was: first chronic phase (n = 10), second chronic phase (n = 2), accelerated phase (n = 2), and blastic crisis (n = 2). The progression rate was significantly lower in patients treated with IM than in those treated without IM (0 vs. 28.6%, p = 0.006). In summary, the survival outcomes of pediatric patients with CML were dramatically improved by treatment with IM compared to HSCT.
Authors:
Hideki Muramatsu; Yoshiyuki Takahashi; Hirotoshi Sakaguchi; Akira Shimada; Nobuhiro Nishio; Asahito Hama; Sayoko Doisaki; Hiroshi Yagasaki; Kimikazu Matsumoto; Koji Kato; Seiji Kojima
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-14
Journal Detail:
Title:  International journal of hematology     Volume:  -     ISSN:  1865-3774     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma-Cho, Showa-ku, Nagoya, Aichi, 466-8650, Japan.
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