Document Detail


Excellent lithium responders have normal cognitive functions and plasma BDNF levels.
MedLine Citation:
PMID:  20392298     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In bipolar patients, neuropsychological and biochemical disturbances persist into the remission period. Excellent lithium responders (ELRs) comprise around one third of lithium-treated patients and have total remission of recurrences on lithium monotherapy. The objective of the study was to assess the performance on neuropsychological tests and to measure brain-derived neurotrophic factor (BDNF) plasma levels in ELRs compared to patients where the effect of lithium was not optimal, and with matched healthy control subjects. The study was performed with 60 patients on prophylactic lithium treatment, 13 of whom were ELRs, and with 60 matched healthy controls. Neuropsychological tests from the CANTAB battery measuring spatial working memory and sustained attention were used. ELRs performed better on all neuropsychological tests, and had higher plasma BDNF levels than the remaining lithium patients but not different from those of healthy controls. ELRs may constitute a specific subgroup of bipolar patients in which long-term lithium administration can produce complete normality.
Authors:
Janusz K Rybakowski; Aleksandra Suwalska
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-04-15
Journal Detail:
Title:  The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)     Volume:  13     ISSN:  1469-5111     ISO Abbreviation:  Int. J. Neuropsychopharmacol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-18     Completed Date:  2011-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815893     Medline TA:  Int J Neuropsychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  617-22     Citation Subset:  IM    
Affiliation:
Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland. rybakows@wlkp.top.pl
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Bipolar Disorder / blood*,  drug therapy,  psychology*
Brain-Derived Neurotrophic Factor / blood*
Cognition / drug effects,  physiology*
Female
Humans
Lithium / blood,  pharmacology,  therapeutic use*
Male
Middle Aged
Neuropsychological Tests*
Chemical
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 7439-93-2/Lithium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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