Document Detail


Exanthematic diseases during pregnancy and attention-deficit/hyperactivity disorder (ADHD).
MedLine Citation:
PMID:  16061411     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rash causing viral diseases may be transmitted during pregnancy, causing severe congenital disease. Although neurological and psychiatric disorders are common consequences of congenital rubella, children born to women who developed a viral rash during pregnancy do not appear to be at increased risk of these disorders if they were asymptomatic at birth. In a case-control study conducted to evaluate risk factors for ADHD, we found an increased risk of this disorder among children born to women experiencing a viral rash during pregnancy. The viral rash (i.e. measles, varicella, or rubella) was reported by 4 of 71 mothers of children with ADHD and none of the 118 controls' mothers (P<0.01). The difference remained statistically significant after adjusting for potential confounders (i.e. other factors found associated with ADHD, such as gender and familiarity). Although, the viral disease reported by the mothers, in accordance with their physician's diagnosis, did not represent a homogeneous nosological group, the unexpectedly high rate found among ADHD cases' mothers suggest a role for viral diseases occurring during pregnancy in the development of ADHD.
Authors:
Carla Arpino; Maria Marzio; Luigi D'Argenzio; Benedetta Longo; Paolo Curatolo
Publication Detail:
Type:  Journal Article     Date:  2005-08-02
Journal Detail:
Title:  European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society     Volume:  9     ISSN:  1090-3798     ISO Abbreviation:  Eur. J. Paediatr. Neurol.     Publication Date:  2005  
Date Detail:
Created Date:  2005-11-21     Completed Date:  2007-04-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9715169     Medline TA:  Eur J Paediatr Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  363-5     Citation Subset:  IM    
Affiliation:
Department of Neuroscience, Pediatric Neurology and Psychiatry Unit, Tor Vergata University of Rome, Rome, Italy. carla.arpino@uniroma2.it
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MeSH Terms
Descriptor/Qualifier:
Attention Deficit Disorder with Hyperactivity / etiology*
Case-Control Studies
Chickenpox / complications
Child
Exanthema / epidemiology,  virology*
Female
Humans
Incidence
Male
Measles / complications
Pregnancy
Pregnancy Complications, Infectious*
Risk Assessment
Rubella / complications
Virus Diseases / complications*

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