Document Detail

Exanthema subitum and human herpesvirus 6 infection: clinical observations in fifty-seven cases.
MedLine Citation:
PMID:  8383833     Owner:  NLM     Status:  MEDLINE    
Exanthema subitum had been speculated to be a viral disease although its pathogen is unknown. Human herpesvirus 6 (HHV-6), first isolated in 1986, was proved by Yamanishi et al. to be the causal agent of exanthema subitum. To evaluate the role of HHV-6 as the causal agent in clinically diagnosed exanthema subitum, we tested for HHV-6 antibody in 57 infants with clinical exanthema subitum and exanthema subitum-like rash without fever. Of the 53 patients with clinical exanthema subitum 43 showed seroconversion or a significant rise in antibody titer to HHV-6, 7 were seropositive without significant rise and 3 remained seronegative. The clinical manifestations of these 43 infants with serologically confirmed HHV-6 infection were consistent with the classical characteristics of exanthema subitum. The 4 patients with atypical exanthema subitum showed significant rises in antibody titer. Our results therefore show that the majority of cases with typical clinical manifestations of exanthema subitum had HHV-6 infection. Most cases with HHV-6 infection had the typical clinical course of exanthema subitum, and a few cases might show an afebrile exanthema subitum-like rash.
K Okada; K Ueda; K Kusuhara; C Miyazaki; K Tokugawa; M Hirose; K Yamanishi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  12     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-04-12     Completed Date:  1993-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  204-8     Citation Subset:  IM    
Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Antibodies, Viral / analysis
Exanthema Subitum / diagnosis,  microbiology*
Herpesviridae Infections / diagnosis*
Herpesvirus 6, Human* / immunology
Serologic Tests
Reg. No./Substance:
0/Antibodies, Viral

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