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Examining the role of cyclin D1 in breast cancer.
MedLine Citation:
PMID:  21675838     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Cyclin D1 overexpression is found in more than 50% of human breast cancers and causes mammary cancer in transgenic mice. Dysregulation of cyclin D1 gene expression or function contributes to the loss of normal cell cycle control during tumorigenesis. Recent studies have demonstrated that cyclin D1 conducts additional specific functions to regulate gene expression in the context of local chromatin, promote cellular migration and inhibit mitochondrial metabolism. It is anticipated that these additional functions contribute to the pathology associated with dysregulated cyclin D1 abundance. This article discusses evidence that examines the significance of cyclin D1 in breast cancer with emphasis on its role in breast cancer stem cell expansion.
Authors:
Marco A Velasco-Velázquez; Zhiping Li; Mathew Casimiro; Emanuele Loro; Nora Homsi; Richard G Pestell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Future oncology (London, England)     Volume:  7     ISSN:  1744-8301     ISO Abbreviation:  Future Oncol     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256629     Medline TA:  Future Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  753-65     Citation Subset:  IM    
Affiliation:
Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México. Apdo. Postal 70-297, México DF, México.
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