Document Detail

Examining the relationship between positive mid-gestational fetal fibronectin assays and histological evidence of acute placental inflammation.
MedLine Citation:
PMID:  17313308     Owner:  NLM     Status:  MEDLINE    
AIMS: Both acute placental inflammation and positive mid-gestational cervico-vaginal fetal fibronectin assays have been independently correlated with preterm delivery. We conducted this study to examine the relationship between positive mid-gestational fetal fibronectin (fFN) assays and histological evidence of acute placental inflammation at delivery among women presenting with symptomatic preterm labor. METHODS: This retrospective chart review included women who underwent cervico-vaginal fFN testing for preterm contractions between 24-34 weeks gestation and also had placental histological analysis after delivery. Women with a multiple gestation, cerclage, preterm premature rupture of membranes, intercourse or vaginal bleeding within 24 h before the assay were excluded. The primary outcome was histological evidence of acute placental inflammation defined as acute chorioamnionitis, acute deciduitis, funisitis, or microabscess formation. RESULTS: Of 82 women who met all study inclusion criteria, 45% were fFN positive. Women with positive assays were no more likely to have histological evidence of acute inflammation noted at birth than women with negative assays (45% vs. 26%, P=0.07). The assay had a sensitivity of 58.6%, specificity of 62.3%, positive predictive value of 46.0%, and negative predictive value of 73.3% for predicting acute inflammation at delivery. CONCLUSIONS: No association exists between positive fetal fibronectin assays and acute histologic placental inflammation at birth.
Aletha Akers; Jason A Jarzembowski; Clark T Johnson; Richard W Lieberman; Vanessa K Dalton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  35     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2007  
Date Detail:
Created Date:  2007-02-22     Completed Date:  2007-04-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  36-42     Citation Subset:  IM    
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Magee-Womens Hospital, Pittsburgh, Pennsylvania 15213, USA.
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MeSH Terms
Chorioamnionitis / metabolism,  pathology*
Fibronectins / metabolism*
Glycoproteins / metabolism*
Obstetric Labor, Premature / metabolism*
Placenta / pathology*
Pregnancy Trimester, Second / metabolism
Pregnancy Trimester, Third / metabolism
Retrospective Studies
Reg. No./Substance:
0/FFN protein, human; 0/Fibronectins; 0/Glycoproteins

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