| Examining MRI Contrast in Three-Dimensional Cell Culture Phantoms with DNA-Templated Nanoparticle Chains. | |
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MedLine Citation:
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PMID: 21381721 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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DNA-templated nanoparticle (NP) chains were examined as potential magnetic resonance imaging (MRI) contrast agents using in vitro environments of the extracellular matrix and tissue. A 3-Tesla clinical MRI scanner was utilized to examine and compare image contrast enhancement caused by dispersed NPs, DNA-templated NP chains, gold-superparamagnetic multi-component NP chains, and polyelectrolyte encapsulated, multi-component NP chains in both T1-weighted and T2-weighted images. In addition, the longitudinal and transverse relaxivity (r1 and r2) changes were measured both in the basement membrane, using Matrigel®, and in the tissue environment, using in vitro 3D cell culture scaffolds. Results suggest that MRI contrast was significantly enhanced from NP chains compared to dispersed NPs in the basement membrane. Polyelectrolyte encapsulation for NP chains produced similar relaxivity to non-encapsulated NP chains due to the enhanced cell uptake of encapsulated NP chains. |
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Authors:
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Hamsa Jaganathan; Daniel L Hugar; Albena Ivanisevic |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-7 |
Journal Detail:
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Title: ACS applied materials & interfaces Volume: - ISSN: 1944-8244 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101504991 Medline TA: ACS Appl Mater Interfaces Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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