Document Detail


Examining the effect of maternal obesity on outcome of labor induction in patients with preeclampsia.
MedLine Citation:
PMID:  20818957     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The objective of this investigation was to evaluate the effect of maternal obesity, as measured by prepregnancy body mass index (BMI), on the mode of delivery in women undergoing indicated induction of labor for preeclampsia.
STUDY DESIGN: Following Institutional Review Board (IRB) approval, patients with preeclampsia who underwent an induction of labor from 1997 to 2007 were identified from a perinatal information database, which included historical and clinical information. Data analysis included bivariable and multivariable analyses of predictor variables by mode of delivery. An artificial neural network was trained and externally validated to independently examine predictors of mode of delivery among women with preeclampsia.
RESULTS: Six hundred and eight women met eligibility criteria and were included in this investigation. Based on multivariable logistic regression (MLR) modeling, a 5-unit increase in BMI yields a 16% increase in the odds of cesarean delivery. An artificial neural network trained and externally validated confirmed the importance of obesity in the prediction of mode of delivery among women undergoing labor induction for preeclampsia.
CONCLUSION: Among patients who are affected by preeclampsia, obesity complicates labor induction. The risk of cesarean delivery is enhanced by obesity, even with small increases in BMI. Prediction of mode of delivery by an artificial neural network performs similar to MLR among patients undergoing labor induction for preeclampsia.
Authors:
Christopher J Robinson; Elizabeth G Hill; Mark C Alanis; Eugene Y Chang; Donna D Johnson; Jonas S Almeida
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  29     ISSN:  1525-6065     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-27     Completed Date:  2011-01-14     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  England    
Other Details:
Languages:  eng     Pagination:  446-56     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cesarean Section
Female
Humans
Labor, Induced*
Obesity*
Pre-Eclampsia*
Pregnancy
ROC Curve
Regression Analysis
Retrospective Studies
Treatment Outcome
Grant Support
ID/Acronym/Agency:
5 T15 LM007438-04/LM/NLM NIH HHS; T15 LM007438/LM/NLM NIH HHS; UL1 RR029882-01/RR/NCRR NIH HHS; UL1 RR029882-017386/RR/NCRR NIH HHS
Comments/Corrections

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