| Examination of variability in arterial blood pressure at rest using spectral analysis in hypertensive patients. | |
| | |
MedLine Citation:
|
PMID: 7759845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
INTRODUCTION: We hypothesize that in essential hypertension sympathetic nervous activity is related to the development of left ventricular hypertrophy, which can be regarded as a measure of the severity of hypertension. METHODS: Using spectral analysis, we studied the short-term variability in resting blood pressure and heart rate in essential hypertensive subjects. We measured blood over 10 min using a Finapres in 88 subjects after 20 min rest. We performed echocardiography to evaluate left ventricular hypertrophy and thereby identified three groups: 23 control subjects (group I), 29 hypertensive subjects (World Health Organization criteria) without left ventricular hypertrophy (group II) and 36 hypertensive subjects with left ventricular hypertrophy (group III). None had been treated for hypertension before the study. RESULTS: The variability in blood pressure over a low-frequency period considered to be a marker of sympathetic activity was significantly increased in group II compared with groups I and III (analysis of covariance taking into account blood pressure and age). The variability in heart rate was similar in groups II and III, but both groups had a significantly reduced variability in heart rate compared with group I. CONCLUSION: These data, which examine globally, using a non-invasive method, all neurohormonal factors associated with the development of left ventricular hypertrophy, demonstrate that, in the time course of hypertension, low-frequency oscillations in blood pressure and heart rate are shifted to a lower level, presumably reflecting altered function of the sympathetic nervous system. We suggest that spectral analysis of blood pressure at rest in hypertensive patients can lead to complementary information to single measures of blood pressure and detect differences in the cardiovascular regulatory system. |
| | |
Authors:
|
J P Siché; F Tremel; V Comparat; R de Gaudemaris; J M Mallion |
Related Documents
:
|
18474835 - Left ventricular filling pressure by doppler echocardiography in patients with end-stag... 3931975 - Haemodynamic effects of nitroglycerin infusion in patients with postinfarction heart fa... 6137935 - Mechanisms of left ventricular filling during increased preload and inotropy. 18059325 - Control of left ventricular mass by moxonidine involves reduced dna synthesis and enhan... 18843165 - Dynamic cerebral autoregulation and cerebrovascular reactivity: a comparative study in ... 17042245 - Cardiovascular regulation response to hypoxia during stepwise decreases from 21% to 15%... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of hypertension Volume: 13 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 1995 Jan |
Date Detail:
|
Created Date: 1995-06-29 Completed Date: 1995-06-29 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 147-53 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine and Cardiology, Centre Hospitalier Universitaire de Grenoble, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Distribution Blood Pressure / physiology* Cross-Sectional Studies Female Heart Rate / physiology Humans Hypertension / complications, physiopathology* Hypertrophy, Left Ventricular / etiology*, physiopathology Male Middle Aged Rest / physiology* Sympathetic Nervous System / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Altered membrane microviscosity in essential hypertension: relationship with family history of hyper...
Next Document: Clinical evidence for an association between left ventricular geometric adaptation and extracardiac ...