| Examination of soluble Fas (sFas) and soluble Fas ligand (sFasL) in patients with burns. | |
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MedLine Citation:
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PMID: 14636754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The FasL-Fas system is one of the recognized apoptosis-inducing systems, and has been determined to have important functions in relation to homeostasis and biological defense mechanisms. In this study, we investigated the serum levels of soluble Fas (sFas), soluble FasL (sFasL) and tumor necrosis factor alpha (TNF-alpha) in patients with burns. The sFas levels were found to be significantly higher in the patients who eventually died as compared to those in the patients who survived (3.9+/-1.8ng/ml versus 2.6+/-1.0ng/ml). On the other hand, the sFasL levels were significantly higher in the patients who survived (61.5+/-29.9ng/ml versus 37.2+/-14.4ng/ml) than in those who eventually died. A positive correlation was noted between the TNF-alpha level and the sFas level, and a negative correlation was observed between the TNF-alpha level and the sFasL level. These findings suggest that worsening of the condition of a burns patient may be related to changes in the Fas-FasL system. |
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Authors:
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Yasuhiko Yamada; Shigeatsu Endo; Hajime Nakae; Hideyuki Makabe; Nobuhiro Sato; Go Wakabayashi; Michihiko Kitamura; Katsuya Inada; Shigehiro Sato |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Burns : journal of the International Society for Burn Injuries Volume: 29 ISSN: 0305-4179 ISO Abbreviation: Burns Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-11-25 Completed Date: 2004-03-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8913178 Medline TA: Burns Country: England |
Other Details:
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Languages: eng Pagination: 799-802 Citation Subset: IM |
Affiliation:
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Department of Critical Care Medicine, Iwate Medical University School of Medicine, 19-1 Uchimaru, 020-8505, Morioka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antigens, CD95 / blood* Apoptosis Burns / blood*, mortality Disease Progression Fas Ligand Protein Humans Membrane Glycoproteins / blood* Middle Aged Statistics, Nonparametric Tumor Necrosis Factor-alpha / analysis |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD95; 0/FASLG protein, human; 0/Fas Ligand Protein; 0/Membrane Glycoproteins; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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