Document Detail


Examination of pineal indoles and 6-methoxy-2-benzoxazolinone for antioxidant and antimicrobial effects.
MedLine Citation:
PMID:  11701394     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxidative modification of low density lipoprotein (LDL) induced by free radicals is implicated in the development of atherosclerosis. The aim of the present study was to examine the ability of various pineal indoles in inhibiting LDL oxidation which is accompanied by an increase in mobility in agarose gel electrophoresis and by an augmented generation of thiobarbituric acid-reactive substance induced by Cu2+. It was found that the order of potencies in inhibiting malondialdehyde formation was 5-hydroxytryptamine (serotonin)>5-hydroxytryptophol and 5-hydroxyindole-3-acetic acid when tested at 4 mM. 5-methoxytryptamine was as effective as 5-hydroxytryptophol and 5-hydroxyindole-3-acetic acid when tested at 4 mM but was inactive at 1 mM. 5-methoxytryptophol was marginally active at 4 mM. Melatonin, 5-methoxyindole-3-acetic acid and 6-methoxy-2-benzoxazolinone were inactive even at 4 mM. The ranking of antioxidative potencies as reflected in the shift of mobility in agar gel electrophoresis was 5-hydroxytryptamine>5-methoxytryptamine>5-hydroxyindole-3-acetic acid and 5-methoxytryptophol>5-hydroxytryptophol and melatonin. Another aim of this investigation was to ascertain the action of the aforementioned pineal indoles on the enhanced lipid peroxidation brought about in the mouse kidney and liver by intraperitoneal administrations of carbon tetrachloride. It was found that all pineal indoles tested demonstrated an inhibitory effect in the kidney but not in the liver. 6-methox-2-benzoxazolinone and 5-methoxyindole-3-acetic acid exerted antifungal activity against Mycosphaerella arachidicola, Botrytis cinerea and Physalospora piricola. 6-methoxy-2-benzoxazolinone exhibited antibacterial activity against Proteus vulgaris and 5-methoxytryptamine against Staphylocccus aureus and Bacillus subtilis. Other pineal indoles did not possess antifungal or antibacterial action.
Authors:
H X Wang; F Liu; T B Ng
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP     Volume:  130     ISSN:  1532-0456     ISO Abbreviation:  Comp. Biochem. Physiol. C Toxicol. Pharmacol.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-09     Completed Date:  2002-03-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100959500     Medline TA:  Comp Biochem Physiol C Toxicol Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  379-88     Citation Subset:  IM    
Affiliation:
Department of Microbiology, College of Biological Science, China Agricultural University, Beijing, PR China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Infective Agents / pharmacology*
Antifungal Agents / pharmacology*
Antioxidants / pharmacology*
Benzoxazoles / pharmacology*
Carbon Tetrachloride / administration & dosage,  pharmacology
Indoles / analysis,  pharmacology*
Injections, Intraperitoneal
Kidney / drug effects,  metabolism
Lipid Peroxidation / drug effects
Lipoproteins, LDL / metabolism
Liver / drug effects,  metabolism
Male
Malondialdehyde / antagonists & inhibitors
Mice
Mice, Inbred BALB C
Microbial Sensitivity Tests
Pineal Gland / chemistry*
Thiobarbituric Acid Reactive Substances / analysis
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Antifungal Agents; 0/Antioxidants; 0/Benzoxazoles; 0/Indoles; 0/Lipoproteins, LDL; 0/Thiobarbituric Acid Reactive Substances; 532-91-2/6-methoxybenzoxazolinone; 542-78-9/Malondialdehyde; 56-23-5/Carbon Tetrachloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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