Document Detail

Examination of mitral regurgitation with a goat heart model for the development of intelligent artificial papillary muscle.
MedLine Citation:
PMID:  23367454     Owner:  NLM     Status:  MEDLINE    
Annuloplasty for functional mitral or tricuspid regurgitation has been made for surgical restoration of valvular diseases. However, these major techniques may sometimes be ineffective because of chamber dilation and valve tethering. We have been developing a sophisticated intelligent artificial papillary muscle (PM) by using an anisotropic shape memory alloy fiber for an alternative surgical reconstruction of the continuity of the mitral structural apparatus and the left ventricular myocardium. This study exhibited the mitral regurgitation with regard to the reduction in the PM tension quantitatively with an originally developed ventricular simulator using isolated goat hearts for the sophisticated artificial PM. Aortic and mitral valves with left ventricular free wall portions of isolated goat hearts (n=9) were secured on the elastic plastic membrane and statically pressurized, which led to valvular leaflet-papillary muscle positional change and central mitral regurgitation. PMs were connected to the load cell, and the relationship between the tension of regurgitation and PM tension were measured. Then we connected the left ventricular specimen model to our hydraulic ventricular simulator and achieved hemodynamic simulation with the controlled tension of PMs.
Y Shiraishi; T Yambe; M Yoshizawa; H Hashimoto; A Yamada; H Miura; M Hashem; T Kitano; T Shiga; D Homma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2012     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2012  
Date Detail:
Created Date:  2013-01-31     Completed Date:  2013-09-17     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6649-52     Citation Subset:  IM    
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MeSH Terms
Artificial Organs*
Computer Simulation
Equipment Design
Heart / physiology*,  physiopathology
Heart Ventricles / pathology
Mitral Valve Insufficiency / etiology*,  physiopathology,  surgery
Myocardium / metabolism
Papillary Muscles / physiopathology*
Prosthesis Design

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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