Document Detail

Examination of gender effect in birth weight and miscarriage associations with childhood cancer (United Kingdom).
MedLine Citation:
PMID:  17206531     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Higher birth weight and maternal history of miscarriage has been associated with an increased risk of childhood leukemia. The possibility that this association may be sex-specific has not been explored in detail in previous studies. METHODS: In a retrospective case-control study, 732 childhood (< or =14 years) cancer cases from a population-based Registry in Northern England whose hospital birth records could be accessed and 3,723 controls matched for date and hospital of birth to the cases were compared. We examined birth weight for sex-specific associations with childhood cancer. Conditional logistic regression analysis was used for statistical evaluation of associations. RESULTS: In acute lymphoblastic leukemia (ALL) (225 cases and 1,163 matched controls), birth weight and sex showed a strong interaction (P = 0.003). In boys with ALL, but not in girls, there was a nonlinear association with birth weight (P for trend = 0.008; OR = 3.05 for the highest quintile compared to the second lowest quintile, 95% CI = 1.40-6.64; P = 0.005). When birth weights were adjusted using UK standards for gestational age and sex, the risk associations were similar in statistical significance and magnitude. Maternal history of miscarriage showed an association with all cancers and individually with ALL. The miscarriage association with ALL was statistically significant in boys only (OR = 1.91, 95% CI = 1.07-3.42; P = 0.03). A multivariable model for ALL containing other examined maternal and reproductive variables confirmed the independence of the birth weight and miscarriage associations. There was no birth weight or miscarriage associations in other cancers. CONCLUSIONS: This study confirmed the risk associations with birth weight and miscarriages in childhood ALL. Statistically significant association of size at birth suggested marked differences in etiology between girls and boys.
M Tevfik Dorak; Mark S Pearce; Donna M Hammal; Richard J Q McNally; Louise Parker
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-01-06
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  18     ISSN:  0957-5243     ISO Abbreviation:  Cancer Causes Control     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-07     Completed Date:  2007-05-15     Revised Date:  2008-04-11    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  219-28     Citation Subset:  IM    
Paediatric and Lifecourse Epidemiology Research Group, Sir James Spence Institute, School of Clinical Medical Sciences, Newcastle University, Newcastle-upon-Tyne, UK.
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MeSH Terms
Abortion, Habitual / epidemiology*
Birth Weight*
Case-Control Studies
Child, Preschool
Great Britain / epidemiology
Infant, Newborn
Odds Ratio
Precursor Cell Lymphoblastic Leukemia-Lymphoma / epidemiology*
Retrospective Studies
Sex Factors
Comment In:
Cancer Causes Control. 2007 Dec;18(10):1227-8; author reply 1229   [PMID:  17828442 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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