| Examination of the effects of vardenafil on esophageal function using multichannel intraluminal impedance and manometry. | |
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MedLine Citation:
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PMID: 23106000 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: To evaluate the effects of the phosphodiesterase type 5 (PDE5) inhibitor vardenafil on esophageal function, including bolus transit, using multichannel intraluminal impedance and esophageal manometry (MII-EM). METHODS: Sixteen healthy volunteers (15 men) underwent an MII-EM study including 10 liquid swallows and 10 viscous swallows in a seated position after fasting. Then, each subject was asked to ingest 50 mL distilled water or 10 mg vardenafil dissolved in 50 mL water, in a double-blind manner. After 25 minutes, the MII-EM study was repeated. RESULTS: Eight men received vardenafil and eight subjects received water. Resting and residual lower esophageal sphincter pressures differed significantly only in the vardenafil group (from 18 ± 6.7 to 6.6 ± 5.3 mmHg, P < 0.001 and from 4.9 ± 2.6 to 2.1 ± 3.6 mmHg, P = 0.006, respectively). Mean distal esophageal amplitude decreased significantly only in the vardenafil group (from 86.7 ± 41.6 to 34.0 ± 38.0 mmHg, P < 0.05). Complete bolus transits of liquid and viscous meals decreased significantly only after vardenafil ingestion (from 80.2% ± 13.8% to 49.4% ± 27.9%, P < 0.05 and from 72.8% ± 33.6% to 21.5% ± 29.0%, P = 0.01, respectively). CONCLUSIONS: Vardenafil decreased esophageal bolus transit in the seated position, despite decreased lower esophageal sphincter pressure. |
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Authors:
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Tae Hee Lee; Joon Seong Lee; Su Jin Hong; Seong Ran Jeon; Wan Jung Kim; Hyun Gun Kim; Joo Young Cho; Jin-Oh Kim |
Publication Detail:
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Type: Journal Article Date: 2012-10-09 |
Journal Detail:
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Title: Journal of neurogastroenterology and motility Volume: 18 ISSN: 2093-0887 ISO Abbreviation: J Neurogastroenterol Motil Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-29 Completed Date: 2012-10-30 Revised Date: 2013-03-21 |
Medline Journal Info:
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Nlm Unique ID: 101530189 Medline TA: J Neurogastroenterol Motil Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 399-405 Citation Subset: - |
Affiliation:
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Institute for Digestive Research, Digestive Disease Center, Soonchunhyang University Seoul Hospital, Seoul, Korea. |
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