Document Detail

Examination of the direct effects of nicorandil, verapamil, propranolol, and nitroglycerin on the hypoxic canine myocardium.
MedLine Citation:
PMID:  2447431     Owner:  NLM     Status:  MEDLINE    
Effects of intracoronary administration of verapamil (VER), nitroglycerin (TNG), propranolol (PRO), and nicorandil (NIC) on regional hypoxia were examined in 39 open-chest dogs. Distal left anterior descending coronary artery was perfused for 5 min with deoxygenated Krebs-Henseleit solution (KHS) in group 1 (n = 9), VER-containing (1.3 mg/dl) KHS in group 2 (n = 9), TNG-containing (0.5 mg/dl) KHS in group 3 (n = 7), PRO-containing (0.4 or 0.8 mg/dl) KHS in group 4 (n = 7), and NIC-containing (0.5 or 2.5 mg/dl) KHS in group 5 (n = 7). Transmural biopsy at 5 min revealed a less severe metabolic deterioration in the hypoxic myocardium in groups 2, 4, and 5, as evidenced by higher ATP content (2.99 +/- 0.73, 2.81 +/- 0.35, and 3.14 +/- 1.20 mumol/g in groups 2, 4, and 5, respectively) and lower lactate accumulation (5.16 +/- 0.59, 5.62 +/- 1.44, and 5.05 +/- 1.12 mumol/g in groups 2, 4, and 5, respectively) compared with those in group 1 (2.09 +/- 0.45 mumol/g in ATP and 8.77 +/- 2.34 mumol/g in lactate). Metabolic preservation by VER, PRO, and NIC were not mediated by changes in hemodynamics and regional myocardial contraction. On the other hand, any significant protective effects were not noted in group 3, despite a significant reduction in rate-pressure products. Under an aerobic condition these agents affected regional myocardial contraction in a different manner from each other.
Y Nakamura; S Kojima; H Mori; S Abe; R Miyamori; T Miyazaki; K Sakurai; S Hattori; M Takahashi
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  10 Suppl 8     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1987  
Date Detail:
Created Date:  1988-02-02     Completed Date:  1988-02-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S92-7     Citation Subset:  IM    
Department of Medicine, School of Medicine, Keio University, Tokyo, Japan.
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MeSH Terms
Coronary Disease / physiopathology*
Hemodynamics / drug effects
Myocardium / metabolism
Niacinamide / analogs & derivatives,  pharmacology
Nitroglycerin / pharmacology
Propranolol / pharmacology
Vasodilator Agents / pharmacology*
Verapamil / pharmacology
Reg. No./Substance:
0/Vasodilator Agents; 52-53-9/Verapamil; 525-66-6/Propranolol; 55-63-0/Nitroglycerin; 65141-46-0/Nicorandil; 98-92-0/Niacinamide

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