Document Detail

Exaggeration of wrinkles after botulinum toxin injection for forehead horizontal lines.
MedLine Citation:
PMID:  21747624     Owner:  NLM     Status:  PubMed-not-MEDLINE    
There have been no long-term complications or life-threatening adverse effects related to botulinum toxin treatment for any cosmetic indications. Nevertheless, there are well-known, mild side effects of botulinum toxin treatment on the upper face, though most of them are self limited with time. However, excluding brow ptosis, reports about site specific side effects are few and anecdotal. We experienced cases of exaggeration of wrinkles after botulinum toxin injection for forehead horizontal lines, and report them here. In our cases, new appearance of a noticeable glabellar protrusion following botulinum toxin injection on the forehead was observed in 2 patients. Also, a new deep wrinkle on one side of the forehead just above the eyebrow appeared in another 2 patients. The exaggerated wrinkles nearly disappeared without treatment by week 4 in all subjects. These exaggerations of wrinkles may be caused by hyperactivity and overcompensation of untreated muscles. With the increasing availability of diverse botulinum toxin for cosmetic purposes, physicians and patients should be aware of this temporary change after therapeutic injections. We recommend explaining this possible effect prior to injection, for better understanding of treatment for cosmetic indications.
Seong Min Kang; Ashley Feneran; Jae Kyung Kim; Ounjae Park; Jeong Eun Kim; Chong Hyun Won; Sungeun Chang; Mi Woo Lee; Jee Ho Choi; Kee Chan Moon; Choon Shik Youn; Soyun Cho; Sang Hyub Lee
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Publication Detail:
Type:  Journal Article     Date:  2011-05-27
Journal Detail:
Title:  Annals of dermatology     Volume:  23     ISSN:  2005-3894     ISO Abbreviation:  Ann Dermatol     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-07-12     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8916577     Medline TA:  Ann Dermatol     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  217-21     Citation Subset:  -    
Department of Dermatology, Asan Medical Center, Seoul, Korea.
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