Document Detail


Exaggeration of blood pressure-related hypoalgesia and reduction of blood pressure with low frequency transcutaneous electrical nerve stimulation.
MedLine Citation:
PMID:  12212639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Reduced pain perception has been observed in hypertensive individuals and normotensive individuals at risk for high blood pressure and may involve increased endogenous opioid release or receptor sensitivity. The present study examined the issue by administering two subjectively similar but physiologically different forms of the pain-reducing procedure transcutaneous electrical nerve stimulation (TENS). Men varying in resting blood pressure and parental history of hypertension participated in three testing sessions during which was presented (a) high-frequency (100 Hz) TENS; (b) low-frequency (2 Hz) TENS, the type believed to elicit endogenous opioid activity; or (c) no-TENS stimulation. Measurements of blood pressure (BP) and other physiological variables were obtained during this period. Afterwards, two pain stimuli were presented: a series of electric shocks and 5 min of arm ischemia. There was a significant negative association between pain and resting systolic blood pressure (SBP), and pain and parental history of hypertension in the no-TENS and high-frequency TENS conditions that was significantly strengthened by administration of low-frequency TENS. As well, low-frequency TENS produced a modest but significant acute reduction in SBP, especially among those with higher resting levels. These results provide further evidence that opioid mechanisms are involved in blood pressure-related hypoalgesia and blood pressure regulation.
Authors:
Tavis S Campbell; Blaine Ditto
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychophysiology     Volume:  39     ISSN:  0048-5772     ISO Abbreviation:  Psychophysiology     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-09-05     Completed Date:  2002-10-01     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0142657     Medline TA:  Psychophysiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  473-81     Citation Subset:  IM    
Affiliation:
Department of Psychology, McGill University, Montreal, Quebec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / physiology*
Galvanic Skin Response
Humans
Hypertension / genetics,  physiopathology*,  psychology
Male
Pain / physiopathology*
Pain Measurement
Transcutaneous Electric Nerve Stimulation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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