| Exaggerated pulmonary hypertension during mild exercise in chronic mountain sickness. | |
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MedLine Citation:
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PMID: 19783668 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Chronic mountain sickness (CMS) is an important public health problem and is characterized by exaggerated hypoxemia, erythrocytosis, and pulmonary hypertension. While pulmonary hypertension is a leading cause of morbidity and mortality in patients with CMS, it is relatively mild and its underlying mechanisms are not known. We speculated that during mild exercise associated with daily activities, pulmonary hypertension in CMS is much more pronounced. METHODS: We estimated pulmonary artery pressure by using echocardiography at rest and during mild bicycle exercise at 50 W in 30 male patients with CMS and 32 age-matched, healthy control subjects who were born and living at an altitude of 3,600 m. RESULTS: The modest, albeit significant difference of the systolic right-ventricular-to-right-atrial pressure gradient between patients with CMS and controls at rest (30.3 +/- 8.0 vs 25.4 +/- 4.5 mm Hg, P 5 .002) became more than three times larger during mild bicycle exercise (56.4 +/- 19.0 vs 39.8 +/- 8.0 mm Hg, P < .001). CONCLUSIONS: Measurements of pulmonary artery pressure at rest greatly underestimate pulmonary artery pressure during daily activity in patients with CMS. The marked pulmonary hypertension during mild exercise associated with daily activity may explain why this problem is a leading cause of morbidity and mortality in patients with CMS. |
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Authors:
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Thomas Stuber; Claudio Sartori; Marcos Schwab; Pierre-Yves Jayet; Stefano F Rimoldi; Sophie Garcin; Sébastien Thalmann; Hilde Spielvogel; Carlos Salinas Salmòn; Mercedes Villena; Urs Scherrer; Yves Allemann |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-25 |
Journal Detail:
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Title: Chest Volume: 137 ISSN: 1931-3543 ISO Abbreviation: Chest Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-05 Completed Date: 2010-03-11 Revised Date: 2010-09-15 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 388-92 Citation Subset: AIM; IM |
Affiliation:
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University Hospital of Bern, Cardiology, Bern, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Altitude Sickness
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complications*,
epidemiology,
physiopathology Bolivia / epidemiology Chronic Disease Exercise / physiology* Exercise Test / adverse effects, methods* Humans Hypertension, Pulmonary / epidemiology, etiology*, physiopathology Male Middle Aged Morbidity / trends Prognosis Pulmonary Wedge Pressure / physiology* Survival Rate / trends |
| Comments/Corrections | |
Comment In:
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Chest. 2010 Sep;138(3):757-8; author reply 758
[PMID:
20823008
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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