Document Detail

Exaggerated nicotine-induced norepinephrine release from atherosclerotic rabbit hearts.
MedLine Citation:
PMID:  4060165     Owner:  NLM     Status:  MEDLINE    
Excessive cigarette smoking acts synergistically with atheromatous coronary artery disease to greatly enhance the risk of acute myocardial infarction. To explore a possible mechanism of this relation, the present study tested the hypotheses that diet-induced atherosclerosis in rabbits is associated with an increase in myocardial (-)-norepinephrine content and that the increased (-)-norepinephrine can be released by nicotine. Adult male rabbits were rendered atherosclerotic by feeding them a standard laboratory diet enriched with 2% cholesterol. After 12-13 weeks on the diet, hearts were excised and retroperfused according to the Langendorff technique. There were no differences between control and atherosclerotic animals in terms of baseline (-)-norepinephrine concentration in the coronary effluent. However, increases in effluent (-)-norepinephrine concentration provoked by 10 micrograms and 30 micrograms nicotine were significantly greater in atherosclerotic hearts than in controls. Similarly, myocardial tissue from atherosclerotic animals contained significantly more (-)-norepinephrine than controls. These observations suggest that diet-induced atherosclerosis in rabbits is associated with an increase in myocardial (-)-norepinephrine content and that the augmented (-)-norepinephrine pool can be mobilized by nicotine.
M N Gillespie; J O Owasoyo; J A Kiritsy-Roy; W N O'Connor; G R Van Loon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicology     Volume:  37     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-12-05     Completed Date:  1985-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  147-57     Citation Subset:  IM    
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MeSH Terms
Arteriosclerosis / etiology,  metabolism*,  pathology
Cholesterol, Dietary / adverse effects
Coronary Vessels / pathology
Epinephrine / analysis,  metabolism
Heart / drug effects*
Myocardial Contraction / drug effects
Myocardial Infarction / etiology
Myocardium / metabolism*
Nicotine / pharmacology*
Norepinephrine / analysis,  metabolism*
Reg. No./Substance:
0/Cholesterol, Dietary; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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