| Exaggerated increase in cardiac output during exercise in patients with peripheral high-flow arteriovenous malformations. | |
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MedLine Citation:
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PMID: 21109459 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE: To test the hypothesis that cardiac output (Q) in patients with arteriovenous malformations (AVMs) is normal at rest and increases disproportionately during exercise. MATERIALS AND METHODS: Q was measured in eight patients with large peripheral AVMs and in nine healthy subjects using a noninvasive carbon dioxide (CO₂)-based differential Fick method. Subjects were tested while seated at rest and during mild exercise (repeated leg straightening while sitting). Oxygen consumption (VO₂) was monitored as an index of the degree of exercise. RESULTS: Average resting Q was similar between AVM patients and healthy subjects (7.40 L/min ± 3.29 vs 6.13 L/min ± 0.94, respectively, P = .29). During exercise, AVM patients showed a smaller increment in VO₂ (0.50 L/min ± 0.11 vs 0.78 L/min ± 0.26, P = .012) but with more apparent effort and shortness of breath compared with healthy subjects. The change in Q per unit change in VO₂ (ΔQ/ΔVO₂) was greater in AVM patients than in healthy subjects (16.00 L/min ± 6.50 vs 9.79 L/min ± 5.33, P < .045). CONCLUSIONS: Exercise intolerance in AVM patients may be due to an imbalance in ΔQ/ΔVO₂ resulting from increased shunting through the AVM. Exercise provocation may increase the sensitivity of Q in the clinical evaluation of AVM patients. |
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Authors:
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Alexandra Mardimae; Jay S Han; David Preiss; Lisa Rodrigues; S Murthy Chennapragada; Marat Slessarev; Martin E Simons; Joseph A Fisher |
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Publication Detail:
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Type: Journal Article Date: 2010-11-25 |
Journal Detail:
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Title: Journal of vascular and interventional radiology : JVIR Volume: 22 ISSN: 1535-7732 ISO Abbreviation: J Vasc Interv Radiol Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203369 Medline TA: J Vasc Interv Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 40-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 SIR. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Anesthesia, University Health Network, University of Toronto, Toronto, Ontario, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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