| Exaggerated differences in pulse wave velocity between left and right sides among patients with anxiety disorders and cardiovascular disease. | |
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MedLine Citation:
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PMID: 17942845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the left-right differences in pulse wave velocity (PWV) measures in normal controls and patients with anxiety disorders and cardiac disease. Pulses from the right and left sides of normal subjects are highly correlated at each segmental level. However, some evidence suggests that the right hemisphere has a greater effect on parasympathetic activity, as there may be a right hemisphere disadvantage in patients with low cardiac vagal function. Decreased vagal function is associated with vascular dysfunction and hypertension. METHODS: We compared normal controls (n = 22), patients with anxiety (n = 26), and patients with cardiovascular disease (n = 72) using the Vascular Profiler (VP-1000), which enables the measurement of ankle and brachial blood pressure (BP) in both arms (brachial), both legs (ankle) and carotid artery, and lead I electrocardiogram and phonocardiogram. Using these signals, PWV, and arterial stiffness index % were calculated for the comparison of these measures on the right and left sides of the body. RESULTS: Patients with anxiety and cardiovascular disease had significantly higher left-right differences in heart-ankle pulse wave velocity, brachial-ankle pulse wave velocity, and arterial stiffness index percentage compared with that of normal controls. Our data also showed significant differences between left-right vascular indices in patients with anxiety and cardiovascular disease (p < .00001); there was no such significant difference in normal controls. CONCLUSIONS: These results may implicate an exaggerated vagal withdrawal in the left extremities resulting in higher PWV in patients with anxiety and cardiovascular illness. |
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Authors:
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Vikram Kumar Yeragani; Rahul Kumar; Karl Juergen Bar; Pratap Chokka; Manuel Tancer |
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Publication Detail:
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Type: Journal Article Date: 2007-10-17 |
Journal Detail:
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Title: Psychosomatic medicine Volume: 69 ISSN: 1534-7796 ISO Abbreviation: Psychosom Med Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-30 Completed Date: 2007-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376505 Medline TA: Psychosom Med Country: United States |
Other Details:
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Languages: eng Pagination: 717-22 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA. Vikramyershr@yahoo.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Ankle / blood supply Anxiety Disorders / physiopathology* Blood Pressure / physiology* Brachial Artery / physiology Cardiovascular Diseases / physiopathology* Case-Control Studies Elasticity Female Functional Laterality Humans Male Middle Aged Vagus Nerve / physiology |
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