Document Detail

Exaggerated atrial natriuretic peptide release during acute exercise in essential hypertension.
MedLine Citation:
PMID:  2975706     Owner:  NLM     Status:  MEDLINE    
The effects of acute exercise on plasma concentrations of atrial natriuretic peptide (ANP), arginine vasopressin (AVP), and plasma renin activity (PRA) were studied in 13 patients with previously untreated essential hypertension, and 8 matched normotensive control subjects. Resting levels of ANP and PRA were similar in the two groups, while resting AVP concentrations were 1.4 times higher in hypertensive subjects. Graded exercise was performed on a bicycle ergometer with workload increased each minute until exhaustion (Wmax). Wmax was higher in normal subjects than in hypertensive patients. Blood pressure and heart rate rose more steeply in hypertensive patients. Plasma ANP increased during acute exercise in both groups, but the average increase in hypertensives was substantially greater than in normal subjects (P less than 0.05). The increase in ANP during exercise was greater in hypertensives with left ventricular (LV) hypertrophy, and there was a positive correlation between LV mass and the percentage rise in ANP during exercise (r = 0.56, P less than 0.005). Plasma AVP did not alter during exercise. Plasma renin concentrations showed a small rise during exercise in both groups, which was 16% less in hypertensive subjects (P less than 0.05). The enhancement of ANP release during exercise in hypertensive subjects may reflect both cardiac structural changes and increased redistribution of blood to the cardiopulmonary compartment.
K Sudhir; R L Woods; G L Jennings; L A Nelson; E Laufer; P I Korner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of human hypertension     Volume:  1     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1989-03-20     Completed Date:  1989-03-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  299-304     Citation Subset:  IM    
Clinical research Unit, Alfred Hospital, Prahran, Victoria, Australia.
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MeSH Terms
Arginine Vasopressin / blood
Atrial Natriuretic Factor / blood*
Blood Pressure
Cardiomegaly / blood,  etiology
Hypertension / blood*,  complications,  physiopathology
Middle Aged
Physical Exertion*
Renin / blood
Reg. No./Substance:
113-79-1/Arginine Vasopressin; 85637-73-6/Atrial Natriuretic Factor; EC

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