Document Detail


Exaggerated Inflammatory Response and Bony Resorption From BMP-2 Use in a Pediatric Forearm Nonunion.
MedLine Citation:
PMID:  22119603     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The Food and Drug Administration indicates that bone morphogenetic protein (BMP) products are contraindicated in pediatric patients. The Food and Drug Administration, however, acknowledges the off-label use of BMP in difficult cases. Although the relative safety of BMP in children has been reported for lower-extremity and spine procedures, little information exists for the safety of BMP used in the pediatric upper extremity. We present a case of a massive inflammatory reaction after use of recombinant human BMP-2 for repair of a symptomatic ulnar nonunion in a child. The case illustrates the potential difficulties of using the dose-dependent properties of BMP in the treatment of pediatric upper-extremity nonunions when the dose calculations of BMP for children have not yet been defined.
Authors:
Andrew W Ritting; Elizabeth W Weber; Mark C Lee
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-23
Journal Detail:
Title:  The Journal of hand surgery     Volume:  -     ISSN:  1531-6564     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7609631     Medline TA:  J Hand Surg Am     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.
Affiliation:
Connecticut Children's Medical Center, University of Connecticut, Hartford, CT.
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