| Exact transmission-disequilibrium tests with multiallelic markers. | |
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MedLine Citation:
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PMID: 9271708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The transmission-disequilibrium (TD) test is a powerful method for detecting linkage between marker and disease loci in the presence of linkage disequilibrium. For multiallelic markers, we propose the use of exact tests, which are implemented using both an exact algorithm and Markov chain Monte Carlo simulation. Simulation studies show that exact tests improve both the small sample validity and the power of the TD method. We also compared the usual single-affected-offspring sampling scheme to one in which pairs of affected siblings are sampled. Affected-sib-pair sampling greatly increases the power of the TD method and will be most useful when a sample of affected sib pairs is available from prior linkage studies. |
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Authors:
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M A Cleves; J M Olson; K B Jacobs |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Genetic epidemiology Volume: 14 ISSN: 0741-0395 ISO Abbreviation: Genet. Epidemiol. Publication Date: 1997 |
Date Detail:
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Created Date: 1997-09-30 Completed Date: 1997-09-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8411723 Medline TA: Genet Epidemiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 337-47 Citation Subset: IM |
Affiliation:
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Department of Epidemiology and Biostatistics, Rammelkamp Center for Education and Research, Case Western Reserve University, Cleveland, Ohio, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Alleles Chi-Square Distribution Gene Frequency* Genetic Markers* Genotype Humans Linkage Disequilibrium* Markov Chains Models, Genetic* Models, Statistical* Monte Carlo Method Nuclear Family Polymorphism, Genetic Risk Assessment |
| Grant Support | |
ID/Acronym/Agency:
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GM28356/GM/NIGMS NIH HHS; HL07567/HL/NHLBI NIH HHS; RR03655/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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