| Exacerbation of corneal scarring in HSV-1 gK-immunized mice correlates with elevation of CD8+CD25+ T cells in corneas of ocularly infected mice. | |
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MedLine Citation:
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PMID: 20079918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have shown previously that exacerbation of corneal scarring (CS) in HSV-1 glycoprotein K (gK) immunized mice was associated with CD8+ T cells. In this study, we investigated the type and the nature of the immune responses that are involved in the exacerbation of CS in gK-immunized animals. BALB/c mice were vaccinated with baculovirus expressed gK, gD, or mock-immunized. Twenty-one days after the third immunization, mice were ocularly infected with 2 x 10(5) PFU/eye of virulent HSV-1 strain McKrae. Infiltration of the cornea by CD4+, CD8+, CD25+, CD4+CD25+, CD8+CD25+, CD19+, CD40+, CD40L+, CD62L+, CD95+, B7-1+, B7-2+, MHC-I+, and MHC-II+ cells was monitored by immunohistochemistry, qRT-PCR and FACS at various times post-infection (PI). This study demonstrated for the first time that the presence of CD8+CD25+ T cells in the cornea is correlated with exacerbation of CS in the gK-immunized group. |
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Authors:
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Sariah J Allen; Kevin R Mott; Alexander V Ljubimov; Homayon Ghiasi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-01-18 |
Journal Detail:
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Title: Virology Volume: 399 ISSN: 1096-0341 ISO Abbreviation: Virology Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-03-22 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0110674 Medline TA: Virology Country: United States |
Other Details:
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Languages: eng Pagination: 11-22 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Inc. All rights reserved. |
Affiliation:
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Center for Neurobiology and Vaccine Development, CSMC Burns and Allen Research Institute, Los Angeles, CA 90048, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals CD8-Positive T-Lymphocytes / immunology, virology* Cicatrix / immunology, virology* Cornea / immunology, virology* Female Flow Cytometry Herpesvirus 1, Human* Immunization Interleukin-2 Receptor alpha Subunit / immunology* Keratitis, Herpetic / immunology, virology* Leukemic Infiltration / immunology, virology Mice Mice, Inbred BALB C Spleen / immunology T-Lymphocytes / immunology, virology* Thymus Gland / immunology Viral Proteins / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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EY13431/EY/NEI NIH HHS; EY13615/EY/NEI NIH HHS; R01 EY013431-09/EY/NEI NIH HHS; R01 EY013615-06/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-2 Receptor alpha Subunit; 0/UL53 protein, Human herpesvirus 1; 0/Viral Proteins |
| Comments/Corrections | |
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