Document Detail

Exacerbation of bronchial asthma following treatment with amiodarone. Demonstration of an antiadrenergic effect in vitro.
MedLine Citation:
PMID:  6088179     Owner:  NLM     Status:  MEDLINE    
We describe a patient with bronchial asthma whose respiratory symptoms worsened during treatment and rechallenge with amiodarone. Laboratory studies on cultured pulmonary cells demonstrated an anti-beta-adrenergic effect of amiodarone not due to inhibition of beta-adrenergic receptor binding. Amiodarone should be used with caution in patients with obstructive pulmonary disease.
D Hunt; P Kertes; S Venables; J Callaghan; L C Harrison
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Chest     Volume:  86     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1984 Sep 
Date Detail:
Created Date:  1984-10-11     Completed Date:  1984-10-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  492-4     Citation Subset:  AIM; IM    
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MeSH Terms
Amiodarone / adverse effects*,  pharmacology
Asthma / drug therapy*
Benzofurans / adverse effects*
Bronchial Provocation Tests
Cells, Cultured
Isoproterenol / pharmacology
Lung / drug effects
Middle Aged
Pulmonary Ventilation
Receptors, Adrenergic, beta / drug effects*
Reg. No./Substance:
0/Benzofurans; 0/Receptors, Adrenergic, beta; 1951-25-3/Amiodarone; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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