| Exacerbation of Leishmania (Viannia) shawi infection in BALB/c mice after immunization with soluble antigen from amastigote forms. | |
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MedLine Citation:
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PMID: 21091779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study aimed to evaluate the effects of immunization with soluble amastigote (AmaAg) and promastigote (ProAg) antigens from Leishmania (Viannia) shawi on the course of infection in BALB/c mice. After immunization with AmaAg, the challenged group showed greater lesion size and parasite load in the skin and lymph nodes, associated with diminished interleukin (IL)-2, IL-4, IL-10, interferon (IFN)-γ and nitrate levels in the supernatant of lymph node cell cultures, together with increases in transforming growth factor (TGF)-β concentrations and humoral immune response. In contrast, immunization with ProAg led to smaller lesion size with reduced numbers of viable parasites in the skin. Protection was associated with increases in IL-12, IFN-γ, TGF-β and nitrates and decreases in IL-4 and IL-10 levels. Concerning humoral immune response, a significant reduction in anti-leishmania immunoglobulin G was verified in the ProAg-challenged group. Analysis of these results suggests that AmaAg induced a suppressive cellular immune response in mice, favouring the spread of infection, whereas ProAg induced partial protection associated with increased cellular immune response. |
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Authors:
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Luiz Felipe Domingues Passero; Maria Luiza Antunes Da Costa Bordon; Ana Kely De Carvalho; Luciano Moura Martins; Carlos Eduardo Pereira Corbett; Márcia Dalastra Laurenti |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-14 |
Journal Detail:
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Title: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica Volume: 118 ISSN: 1600-0463 ISO Abbreviation: APMIS Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2011-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8803400 Medline TA: APMIS Country: Denmark |
Other Details:
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Languages: eng Pagination: 973-81 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. Journal Compilation © 2010 APMIS. |
Affiliation:
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Departamento de Patologia, Universidade de São Paulo, Brasil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Protozoan / blood, immunology* Antigens, Protozoan / immunology* Cytokines / immunology Immunization / methods* Leishmania / immunology* Leishmaniasis, Cutaneous / immunology*, parasitology, prevention & control Male Mice Mice, Inbred BALB C Nitric Oxide / immunology Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Protozoan; 0/Antigens, Protozoan; 0/Cytokines; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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