Document Detail


Exacerbated mechanical allodynia in rats with depression-like behavior.
MedLine Citation:
PMID:  18289511     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although a clinical connection between pain and depression has long been recognized, how these two conditions interact remains unclear. Here we report that both mechanical allodynia and depression-like behavior were significantly exacerbated after peripheral nerve injury in Wistar-Kyoto (WKY) rats, a genetic variation of Wistar rats with demonstrable depression-like behavior. Administration of melatonin into the anterior cingular cortex contralateral to peripheral nerve injury prevented the exacerbation of mechanical allodynia with a concurrent improvement of depression-like behavior in WKY rats. Moreover, there was a lower plasma melatonin concentration and a lower melatonin receptor expression in the anterior cingular cortex in WKY rats than in Wistar rats. These results suggest that there exists a reciprocal relationship between mechanical allodynia and depression-like behavior and the melatoninergic system in the anterior cingular cortex might play an important role in the interaction between pain and depression.
Authors:
Qing Zeng; Shuxing Wang; Grewo Lim; Liling Yang; Ji Mao; Backil Sung; Yang Chang; Jeong-Ae Lim; Gongshe Guo; Jianren Mao
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2008-01-26
Journal Detail:
Title:  Brain research     Volume:  1200     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-07-18     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  27-38     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Depressive Disorder / complications*,  genetics,  physiopathology
Disease Models, Animal
Genetic Predisposition to Disease / genetics
Gyrus Cinguli / drug effects,  metabolism*,  physiopathology
Hyperalgesia / drug therapy,  genetics*,  physiopathology
Male
Melatonin / blood,  pharmacology*,  therapeutic use
Neuralgia / drug therapy,  genetics*,  physiopathology
Pain Threshold / drug effects
Peripheral Nerve Injuries
Peripheral Nerves / physiopathology
Peripheral Nervous System Diseases / drug therapy,  genetics,  physiopathology
Physical Stimulation
Rats
Rats, Inbred WKY
Rats, Wistar
Receptors, Melatonin / agonists,  metabolism
Species Specificity
Grant Support
ID/Acronym/Agency:
R01 DE018538/DE/NIDCR NIH HHS; R01 DE018538-01/DE/NIDCR NIH HHS; R01 DE18538/DE/NIDCR NIH HHS; R01 NS042661/NS/NINDS NIH HHS; R01 NS042661-04/NS/NINDS NIH HHS; R01 NS045681/NS/NINDS NIH HHS; R01 NS045681-04/NS/NINDS NIH HHS; R01 NS45681/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Melatonin; JL5DK93RCL/Melatonin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1's attenuation of beta-amyloid pept...
Next Document:  Activation of cerebral peroxisome proliferator-activated receptors gamma exerts neuroprotection by i...