| Ex vivo water diffusion tensor properties of the fibroid uterus at 7 T and their relation to tissue morphology. | |
| | |
MedLine Citation:
|
PMID: 21953730 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE: To investigate the water diffusion tensor properties of ex vivo tissue in the fibroid uterus, including the influence of degeneration, and the relevance of the principal eigenvector orientation to the underlying tissue structure. MATERIALS AND METHODS: Following hysterectomy, high-resolution structural T(2) -weighted and diffusion tensor magnetic resonance imaging (DT-MRI) were performed on nine uteri at 7 T. Mean diffusivity (MD), fractional anisotropy (FA), and principal eigenvector orientation were measured in myometrium and in myxoid and dense tissue in fibroids. Imaging data and measurements of water diffusion parameters were compared with histopathology findings. RESULTS: The nine uteri yielded 23 fibroids. MD was 50% higher in regions of myxoid degeneration compared to dense fibroid tissue (P = 0.001), while myometrium was intermediate in value (dense fibroid tissue, P = 0.15; myxoid degeneration, P = 0.23). FA was lower in dense fibroid tissue than in myometrium (P = 3 × 10(-5) ), but higher than in myxoid tissue (P = 0.003). Principal eigenvector orientation corresponded qualitatively with that of uterine smooth muscle fibers. CONCLUSION: The water diffusion tensor measured ex vivo in the fibroid uterus is a sensitive probe of tissue type, myxoid degeneration, and morphology. J. Magn. Reson. Imaging 2011;. © 2011 Wiley-Liss, Inc. |
| | |
Authors:
|
Michael J Thrippleton; Mark E Bastin; Kirsty I Munro; Alistair R Williams; Anca Oniscu; Maurits A Jansen; Gavin D Merrifield; Graham McKillop; David E Newby; Scott I Semple; Ian Marshall; Hilary O Critchley |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-23 |
Journal Detail:
|
Title: Journal of magnetic resonance imaging : JMRI Volume: - ISSN: 1522-2586 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
|
MRC Centre for Reproductive Health, University of Edinburgh, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc.
Next Document: Aortic valve annulus diameter in chinese patients with severe calcific aortic valve stenosis: Implic...