| Ex vivo perfusion with mitomycin C containing solution prolongs heart graft survival in rats. | |
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MedLine Citation:
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PMID: 17164729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mitomycin C (MMC) is an alkylating agent which suppresses allogeneic T-cell responses. We analyzed the effect of graft perfusion with MMC on transplant survival. Hearts from Brown-Norway (BN) rats were perfused ex vivo with MMC-containing solution, stored and implanted into Lewis (LEW) rats. In order to analyze the in vivo effect of MMC, recipients received MMC posttransplantation or were pretreated with MMC-incubated donor-derived peripheral blood mononuclear cells (PBMCs). The results show that MMC-perfusion significantly prolongs graft survival. Treatment of recipients with MMC has no effect, whereas MMC-treated donor PBMCs injected into the recipient prolong graft survival. Our findings indicate that the targeted perfusion of donor hearts with MMC-containing solution protects the graft from rejection. |
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Authors:
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Daohu Wang; Christian Kleist; Sandra Ehser; Gerhard Opelz; Peter Terness |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Transplantation Volume: 82 ISSN: 0041-1337 ISO Abbreviation: Transplantation Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-13 Completed Date: 2007-03-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0132144 Medline TA: Transplantation Country: United States |
Other Details:
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Languages: eng Pagination: 1537-40 Citation Subset: IM |
Affiliation:
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Institute for Immunology, Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Graft Survival / drug effects* Heart / drug effects* Heart Transplantation* Leukocytes, Mononuclear / drug effects Male Mitomycin / pharmacology* Perfusion Rats Rats, Inbred BN Rats, Inbred Lew Solutions / pharmacology Tissue Donors |
| Chemical | |
Reg. No./Substance:
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0/Solutions; 50-07-7/Mitomycin |
| Comments/Corrections | |
Comment In:
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Transplantation. 2006 Dec 15;82(11):1411-2
[PMID:
17164709
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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