| Ex-vivo measures of muscle mitochondrial capacity reveal quantitative limits of oxygen delivery by the circulation during exercise. | |
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MedLine Citation:
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PMID: 23032701 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Muscle mitochondrial respiratory capacity measured ex-vivo provides a physiological reference to assess cellular oxidative capacity as a component in the oxygen cascade in-vivo. In this review, the magnitude of muscle blood flow and oxygen uptake during exercise involving a small-to-large fraction of the body mass will be discussed in relation to mitochondrial capacity measured ex-vivo. These analyses reveal that as the mass of muscle engaged in exercise increases from one-leg knee extension, to 2-arm cranking, to 2-leg cycling and x-country skiing, the magnitude of blood flow and oxygen delivery decrease. Accordingly, a 2-fold higher oxygen delivery and oxygen uptake per unit muscle mass are seen in-vivo during 1-leg exercise compared to 2-leg cycling indicating a significant limitation of the circulation during exercise with a large muscle mass. This analysis also reveals that mitochondrial capacity measured ex-vivo underestimates the maximal in-vivo oxygen uptake of muscle by up to ∼2-fold. |
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Authors:
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Robert Boushel; Bengt Saltin |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-29 |
Journal Detail:
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Title: The international journal of biochemistry & cell biology Volume: - ISSN: 1878-5875 ISO Abbreviation: Int. J. Biochem. Cell Biol. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-10-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508482 Medline TA: Int J Biochem Cell Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
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Heart & Circulatory Section, Department of Biomedical Sciences, Department of Anaesthesia, Bispebjerg Hospital, University of Copenhagen. Electronic address: boushel@sund.ku.dk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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