Document Detail

Ex-vivo measures of muscle mitochondrial capacity reveal quantitative limits of oxygen delivery by the circulation during exercise.
MedLine Citation:
PMID:  23032701     Owner:  NLM     Status:  Publisher    
Muscle mitochondrial respiratory capacity measured ex-vivo provides a physiological reference to assess cellular oxidative capacity as a component in the oxygen cascade in-vivo. In this review, the magnitude of muscle blood flow and oxygen uptake during exercise involving a small-to-large fraction of the body mass will be discussed in relation to mitochondrial capacity measured ex-vivo. These analyses reveal that as the mass of muscle engaged in exercise increases from one-leg knee extension, to 2-arm cranking, to 2-leg cycling and x-country skiing, the magnitude of blood flow and oxygen delivery decrease. Accordingly, a 2-fold higher oxygen delivery and oxygen uptake per unit muscle mass are seen in-vivo during 1-leg exercise compared to 2-leg cycling indicating a significant limitation of the circulation during exercise with a large muscle mass. This analysis also reveals that mitochondrial capacity measured ex-vivo underestimates the maximal in-vivo oxygen uptake of muscle by up to ∼2-fold.
Robert Boushel; Bengt Saltin
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-29
Journal Detail:
Title:  The international journal of biochemistry & cell biology     Volume:  -     ISSN:  1878-5875     ISO Abbreviation:  Int. J. Biochem. Cell Biol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508482     Medline TA:  Int J Biochem Cell Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ltd.
Heart & Circulatory Section, Department of Biomedical Sciences, Department of Anaesthesia, Bispebjerg Hospital, University of Copenhagen. Electronic address:
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