Document Detail


Ex vivo fucosylation of stem cells to improve engraftment: WO2004094619.
MedLine Citation:
PMID:  20518619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The application is in the field of haematopoietic stem cell (HSC) and umbilical cord blood (CB) transplantation.
OBJECTIVE: It aims at determining an enzymatic procedure to improve the engraftment of CB stem cells to the bone marrow (BM) as well as the rate of success of CB transplantation.
METHODS: Human CB stem cells were treated with alpha1-3 fucosyltransferase VI (FTVI) for 30 min ex vivo prior to transplantation. Human CB stem cells were administered intravenously in irradiated nonobese diabetic/severe combined immune deficiency (NOD/SCID) mice.
RESULTS: Treatment of CB stem cells with FTVI improves their engraftment in the BM of NOD/SCID mice.
CONCLUSION: Treatment of CB stem cells with FTVI, ex vivo prior to transplantation, may reduce the delay of engraftment of CB stem cells to the BM and the risk of early infections associated with CB transplants, particularly in adults. It may improve the outcome and rate of success of CB transplantation. The application claims the use of fucosyltransferase for improving the engraftment of CB HSCs to the BM for the treatment of haematologic diseases. The procedure may be used to improve the engraftment of HSCs from other sources and other types of stem cells, on transplantation, particularly when administered intravenously.
Authors:
Philippe Taupin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert opinion on therapeutic patents     Volume:  20     ISSN:  1744-7674     ISO Abbreviation:  Expert Opin Ther Pat     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-18     Completed Date:  2010-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9516419     Medline TA:  Expert Opin Ther Pat     Country:  England    
Other Details:
Languages:  eng     Pagination:  1265-9     Citation Subset:  IM    
Affiliation:
Dublin City University, School of Biotechnology, Glasnevin, Dublin, Ireland. philippe.taupin@dcu.ie
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Marrow Diseases / therapy
Cord Blood Stem Cell Transplantation / methods*
Fucosyltransferases / chemistry*
Hematologic Diseases / therapy
Hematopoietic Stem Cell Transplantation / methods*
Humans
Mice
Patents as Topic
Treatment Outcome
Chemical
Reg. No./Substance:
EC 2.4.1.-/Fucosyltransferases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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