Document Detail


Ex vivo evaluation of a new extracorporeal lung assist device: NovaLung membrane oxygenator.
MedLine Citation:
PMID:  16288436     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When lung function is compromised,alternative devices need to be deployed in order to maintain blood oxygenation. A new device, NovaLung, has been designed for acute lung failure. We went about evaluating its gas exchange capability. Three calves (79.5 +/- 7.8 kg) were connected to the NovaLung System with a priming volume of 240 mL, gas exchange surface area of 1.3 m2 and exhibiting a biologically coated surface. A standard battery of blood samples were taken before implantation and over a six hour period. Hematocrit remained stable ranging from 27 +/- 4% (baseline) to 29 +/- 5% (6 hrs). Platelets were preserved ranging from 882 +/- 27.4 U/L (baseline) to 734 +/- 147 (6 hrs). LDH remained stable at 719 +/- 85 U/L (baseline) vs 686 +/- 190 U/L (6 hrs) and the pressure drop was maintained below 20 mmHg. Minimal hemolysis was observed. Oxygen transfer peaked at two hours acute extracorporeal lung support (ECLS)with a mean value of 130 +/- 50 ml/min. In conclusion, the device is easy to use,provides adequate O2 and CO2 transfer for partial lung support in an acute setting. Shows minimal signs of hemolysis and platelets levels are maintained throughout the six hour ECLS period.
Authors:
D Jegger; J-P Revelly; J Horisberger; I Mallabiabarrena; I Seigneul; M Jachertz; L K Von Segesser
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  The International journal of artificial organs     Volume:  28     ISSN:  0391-3988     ISO Abbreviation:  Int J Artif Organs     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-11-18     Completed Date:  2006-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802649     Medline TA:  Int J Artif Organs     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  985-99     Citation Subset:  IM    
Affiliation:
Department of Cardio-Vascular Surgery, University Hospital Vaudois (CHUV), Lausanne--Switzerland. David.Jegger@chuv.hospvd.ch
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Flow Velocity / physiology
Blood Pressure / physiology
Cattle
Equipment Design
Equipment Failure Analysis
Extracorporeal Membrane Oxygenation / instrumentation*,  methods
Hematocrit
Lung / blood supply*
Lung Diseases / physiopathology,  therapy
Oxygen / metabolism*
Pulmonary Gas Exchange / physiology*
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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