Document Detail


Ex uno plures: the concealed complexity of bilirubin species in neonatal blood samples.
MedLine Citation:
PMID:  16951014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Blood from jaundiced neonates often contains several isomers of bilirubin in addition to the biosynthetic isomer that causes kernicterus. These isomers are generated during phototherapy or during normal exposure of infants to ambient light. Their presence is generally overlooked or ignored in clinical measurements of circulating bilirubin concentrations and the interpretation of these values. Whether this is justified or clinically important is presently uncertain. However, the presence of isomers may complicate the accurate measurement of free bilirubin concentrations in blood and the use of such values for identifying jaundiced infants at most risk of kernicterus.
Authors:
Antony F McDonagh
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pediatrics     Volume:  118     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-04     Completed Date:  2006-09-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1185-7     Citation Subset:  AIM; IM    
Affiliation:
Division of Gastroenterology and the Liver Center, University of California San Francisco, San Francisco, California 94143-0538, USA. tony.mcdonagh@ucsf.edu
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MeSH Terms
Descriptor/Qualifier:
Bilirubin / blood*,  chemistry*
Humans
Infant, Newborn
Isomerism
Jaundice, Neonatal / blood*,  diagnosis*,  therapy
Phototherapy
Reference Values
Reproducibility of Results
Sensitivity and Specificity
Grant Support
ID/Acronym/Agency:
DK-26307/DK/NIDDK NIH HHS; DK-26743/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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