Document Detail


Ewing's sarcoma cells with CD57-associated increase of tumorigenicity and with neural crest-like differentiation capacity.
MedLine Citation:
PMID:  20104521     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Ewing family of tumors (EFT) is an important group of pediatric malignancies with a guarded prognosis. Little is known about the heterogeneity of EFT cells, and the cellular origin of EFT is disputed. We now add evidence that EFT are heterogeneous by showing that EFT cells from spheres growing in serum-free medium are markedly more tumorigenic than adherently growing EFT cells. Furthermore, EFT cells strongly expressing CD57 (HNK-1), a surface marker for migrating and proliferating neural crest cells, are more tumorigenic than cells with low expression of CD57, possibly mediated in part by enhanced adhesion and invasion. We contribute to the controversy about the cellular origin of EFT by clonal analysis, showing that EFT cells can differentiate similar to neural crest cells. These data increase our knowledge about the pathogenesis and heterogeneity of EFT.
Authors:
Joachim Wahl; Liubov Bogatyreva; Petra Boukamp; Markus Rojewski; Frans van Valen; Jörg Fiedler; Nora Hipp; Klaus-Michael Debatin; Christian Beltinger
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  127     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-27     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1295-307     Citation Subset:  IM    
Affiliation:
University Children's Hospital, Ulm, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, CD57 / physiology*
Cell Differentiation*
Culture Media, Serum-Free
Flow Cytometry
Humans
Mice
Mice, Knockout
Neural Crest / cytology*
Sarcoma, Ewing's / immunology,  pathology*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antigens, CD57; 0/Culture Media, Serum-Free

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