Document Detail


Evolving immune circuits are generated by flexible, motile, and sequential immunological synapses.
MedLine Citation:
PMID:  23278742     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The immune system is made up of a diverse collection of cells, each of which has distinct sets of triggers that elicit unique and overlapping responses. It is correctly described as a 'system' because its overall properties (e.g. 'tolerance', 'allergy') emerge from multiple interactions of its components cells. To mobilize a response where needed, the majority of the cells of the system are obligatorily highly motile and so must communicate with one another over both time and space. Here, we discuss the flexibility of the primary immunological synapse (IS) with respect to motility. We then consider the primary IS as an initiating module that licenses 'immunological circuits': the latter consisting of two or more cell-cell synaptic interactions. We discuss how two or three component immunological circuits interact might with one another in sequence and how the timing, stoichiometry, milieu, and duration of assembly of immunological circuits are likely to be key determinants in the emergent outcome and thus the system-wide immune response. An evolving consideration of immunological circuits, with an emphasis on the cell-cell modules that complement T-antigen-presenting cell interaction, provides a fundamental starting point for systems analysis of the immune response.
Authors:
Audrey Gérard; Peter Beemiller; Rachel S Friedman; Jordan Jacobelli; Matthew F Krummel
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  251     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-06-28     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  80-96     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Communication* / immunology
Cell Movement / immunology
Cellular Microenvironment / immunology
Cytokinesis / immunology
Humans
Immune System*
Immunity, Cellular*
Immunological Synapses / immunology*
Receptor Cross-Talk
Signal Transduction
Grant Support
ID/Acronym/Agency:
P01 HL024136/HL/NHLBI NIH HHS; P01HL024136/HL/NHLBI NIH HHS; P30 DK063720/DK/NIDDK NIH HHS; R01 AI052116/AI/NIAID NIH HHS; R01AI52116/AI/NIAID NIH HHS; U01 CA141451/CA/NCI NIH HHS; U01CA141451/CA/NCI NIH HHS
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