Document Detail


Evolving experience with prevention and treatment of splenic artery syndrome after orthotopic liver transplantation.
MedLine Citation:
PMID:  20180930     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Impaired hepatic arterial perfusion after orthotopic liver transplantation (OLT) may lead to ischemic biliary tract lesions and graft-loss. Hampered hepatic arterial blood flow is observed in patients with hypersplenism, often described as arterial steal syndrome (ASS). However, arterial and portal perfusions are directly linked via the hepatic arterial buffer response (HABR). Recently, the term 'splenic artery syndrome' (SAS) was coined to describe the effect of portal hyperperfusion leading to diminished hepatic arterial blood flow. We retrospectively analyzed 650 transplantations in 585 patients. According to preoperative imaging, 78 patients underwent prophylactic intraoperative ligation of the splenic artery. In case of postoperative SAS, coil-embolization of the splenic artery was performed. After exclusion of 14 2nd and 3rd retransplantations and 83 procedures with arterial interposition grafts, SAS was diagnosed in 28 of 553 transplantations (5.1%). Twenty-six patients were treated with coil-embolization, leading to improved liver function, but requiring postinterventional splenectomy in two patients. Additionally, two patients with SAS underwent splenectomy or retransplantation without preceding embolization. Prophylactic ligation could not prevent SAS entirely (n = 2), but resulted in a significantly lower rate of complications than postoperative coil-embolization. We recommend prophylactic ligation of the splenic artery for patients at risk of developing SAS. Post-transplant coil-embolization of the splenic artery corrected hemodynamic changes of SAS, but was associated with a significant morbidity.
Authors:
Martina T Mogl; Natascha C Nüssler; Sabine J Presser; Petr Podrabsky; Timm Denecke; Christian Grieser; Peter Neuhaus; Olaf Guckelberger
Publication Detail:
Type:  Journal Article     Date:  2010-02-18
Journal Detail:
Title:  Transplant international : official journal of the European Society for Organ Transplantation     Volume:  23     ISSN:  1432-2277     ISO Abbreviation:  Transpl. Int.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908516     Medline TA:  Transpl Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  831-41     Citation Subset:  IM    
Affiliation:
Department of General, Visceral and Transplant Surgery, Charité Campus Virchow, Humboldt-University Berlin, Germany. martina.mogl@charite.de
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Child
Child, Preschool
Delayed Graft Function / epidemiology,  physiopathology,  prevention & control*
Embolization, Therapeutic
Female
Humans
Hypertension, Portal / epidemiology,  prevention & control*,  therapy
Infant
Ligation
Liver Transplantation / adverse effects*,  methods,  physiology
Male
Middle Aged
Portal System / physiopathology
Postoperative Complications* / epidemiology,  surgery,  therapy
Reoperation
Retrospective Studies
Risk Factors
Splenectomy
Splenic Artery / physiopathology*,  surgery
Syndrome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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