Document Detail

Evolving biaxial mechanical properties of mouse carotid arteries in hypertension.
MedLine Citation:
PMID:  21851943     Owner:  NLM     Status:  MEDLINE    
Quantifying the time course of load-induced changes in arterial wall geometry, microstructure, and properties is fundamental to developing mathematical models of growth and remodeling. Arteries adapt to altered pressure and flow by modifying wall thickness, inner diameter, and axial length via marked cell and matrix turnover. To estimate particular biomaterial implications of such adaptations, we used a 4-fiber family constitutive relation to quantify passive biaxial mechanical behaviors of mouse carotid arteries 0 (control), 7-10, 10-14, or 35-56 days after an aortic arch banding surgery that increased pulse pressure and pulsatile flow in the right carotid artery. In vivo circumferential and axial stretches at mean arterial pressure were, for example, 11% and 26% lower, respectively, in hypertensive carotids 35-56 days after banding than in normotensive controls; this finding is consistent with observations that hypertension decreases distensibility. Interestingly, the strain energy W stored in the carotids at individual in vivo conditions was also less in hypertensive compared with normotensive carotids. For example, at 35-56 days after banding, W was 24%, 39%, and 47% of normal values at diastolic, mean, and systolic pressures, respectively. The energy stored during the cardiac cycle, W(sys)-W(dias), also tended to be less, but this reduction did not reach significance. When computed at normal in vivo values of biaxial stretch, however, W was well above normal for the hypertensive carotids. This net increase resulted from an overall increase in the collagen-related anisotropic contribution to W despite a decrease in the elastin-related isotropic contribution. The latter was consistent with observed decreases in the mass fraction of elastin.
J F Eberth; L Cardamone; J D Humphrey
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-08-17
Journal Detail:
Title:  Journal of biomechanics     Volume:  44     ISSN:  1873-2380     ISO Abbreviation:  J Biomech     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-07     Completed Date:  2012-03-26     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2532-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Biomechanical Phenomena
Carotid Artery Diseases / physiopathology
Carotid Artery, Common / physiopathology*
Collagen / metabolism
Disease Models, Animal
Elastin / metabolism
Hypertension / physiopathology*
Mice, Inbred C57BL
Pulsatile Flow
Stress, Mechanical
Grant Support
HL-105297/HL/NHLBI NIH HHS; R01 HL105297/HL/NHLBI NIH HHS; R01 HL105297-01/HL/NHLBI NIH HHS; R01 HL105297-02/HL/NHLBI NIH HHS; R01 HL105297-03/HL/NHLBI NIH HHS
Reg. No./Substance:
9007-34-5/Collagen; 9007-58-3/Elastin

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