Document Detail

Evolutionary trend of foot-and-mouth disease virus in Hong Kong.
MedLine Citation:
PMID:  22472703     Owner:  NLM     Status:  Publisher    
Foot-and-mouth disease is an endemic animal disease in Hong Kong. In this study, a total of 70 clinical specimens were collected from locally infected pigs from 2001 to 2010. Phylogenetic analysis of VP1 sequences reveal that all Hong Kong FMDV serotype O isolates are classified into three lineages: HK-A and HK-B in Cathay topotype, and HK-C in SEA topotype. Regression analysis projects that the time of divergence from the most recent common ancestor of HK-A and HK-B are 1964±12 and 1987±9years respectively. Although HK-B shares a common ancestor with strains that caused outbreak in Taiwan and Philippines, there is no consolidated evidence demonstrating the order of introduction events among these regions. HK-C lineage is the latest FMDV isolated in Hong Kong. This virus is likely adopted from bovine into porcine. As local pigs confer immunity mainly against Cathay topotype viruses, introduction of HK-C viruses have led into an unexpectedly high severity and rapid spreading rate of the disease. A systematic surveillance and communication network is essential to provide accurate information in controlling the pandemics.
Raymond K Hui; Frederick C Leung
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-16
Journal Detail:
Title:  Veterinary microbiology     Volume:  -     ISSN:  1873-2542     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-4-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705469     Medline TA:  Vet Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
School of Biological Sciences, The University of Hong Kong, Hong Kong Special Administrative Region.
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