Document Detail


Evolutionary transience of hypervariable minisatellites in man and the primates.
MedLine Citation:
PMID:  1675801     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using PCR, two minisatellite loci showing extreme repeat-unit copy-number variation in humans have been characterized in great apes and monkeys. In contrast to humans, minisatellite locus MS32 is monomorphic with only 3-4 diverged repeat units in great apes, Old World and New World monkeys, this organization presumably representing the relatively stable ancestral precursor state of the human hypervariable locus. Similarly, minisatellite MS1 shows extreme repeat-copy-number variability in man compared with low copy number and minimal variability in great apes. Analysis of variant repeat units shows that the 5' and 3' regions of MS1 are relatively stable in great apes and man, and that variability in man is confined to the central region of the minisatellite. In contrast to the great apes, MS1 is highly variable in Old World monkeys. These results, as well as computer simulations of minisatellite evolution based on known mutation rates, show that short minisatellites are stable within the genome, and that the degree of polymorphism at a given locus can change dramatically over a short period of evolutionary time. The ability of hypervariable minisatellites to detect highly informative loci by cross-species hybridization is therefore largely unpredictable.
Authors:
I C Gray; A J Jeffreys
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings. Biological sciences / The Royal Society     Volume:  243     ISSN:  0962-8452     ISO Abbreviation:  Proc. Biol. Sci.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-07-22     Completed Date:  1991-07-22     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  101245157     Medline TA:  Proc Biol Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  241-53     Citation Subset:  IM    
Affiliation:
Department of Genetics, University of Leicester, U.K.
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MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
DNA, Satellite / genetics*
Evolution*
Humans
Molecular Sequence Data
Polymerase Chain Reaction
Polymorphism, Genetic
Primates
Repetitive Sequences, Nucleic Acid
Sequence Homology, Nucleic Acid
Species Specificity
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/DNA, Satellite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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