Document Detail

Evolutionary perspectives on the fetal origins hypothesis.
MedLine Citation:
PMID:  15612045     Owner:  NLM     Status:  MEDLINE    
The fetal origins hypothesis, or Barker hypothesis, is both stimulating and challenging for evolutionary human biologists. While evidence of a correlation between conditions around the time of birth and later health outcomes has been presented before, the more recent evidence of a connection between fetal growth and chronic disease risk later in life has attracted considerable attention among epidemiologists and human biologists. Several themes that are fundamental to human biology emerge from an engagement with the fetal origins hypothesis. Among them are the tension between concepts of pathology, constraint, and adaptation; the importance of a life history perspective that embraces the notion of trade-offs; the question of environmental predictability; and the mechanisms of energy mobilization and allocation. Bringing the insights of evolutionary biology to bear on the fetal origins hypothesis illustrates the value of the field now known as evolutionary medicine.
Peter T Ellison
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of human biology : the official journal of the Human Biology Council     Volume:  17     ISSN:  1042-0533     ISO Abbreviation:  Am. J. Hum. Biol.     Publication Date:    2005 Jan-Feb
Date Detail:
Created Date:  2004-12-27     Completed Date:  2005-05-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8915029     Medline TA:  Am J Hum Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-8     Citation Subset:  IM    
Copyright Information:
(c) 2004 Wiley-Liss, Inc.
Department of Anthropology, Harvard University, Cambridge, Massachusetts 02138, USA.
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MeSH Terms
Adaptation, Physiological*
Developmental Biology*
Fetal Development / physiology*
Hypothalamo-Hypophyseal System / growth & development
Neuronal Plasticity / physiology*
Pituitary-Adrenal System / growth & development
Prenatal Exposure Delayed Effects*
Comment In:
Am J Hum Biol. 2005 May-Jun;17(3):381-2   [PMID:  15849708 ]

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