| Evolutionary origin of the cell nucleus and its functional architecture. | |
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MedLine Citation:
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PMID: 20822483 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Understanding the evolutionary origin of the nucleus and its compartmentalized architecture provides a huge but, as expected, greatly rewarding challenge in the post-genomic era. We start this chapter with a survey of current hypotheses on the evolutionary origin of the cell nucleus. Thereafter, we provide an overview of evolutionarily conserved features of chromatin organization and arrangements, as well as topographical aspects of DNA replication and transcription, followed by a brief introduction of current models of nuclear architecture. In addition to features which may possibly apply to all eukaryotes, the evolutionary plasticity of higher-order nuclear organization is reflected by cell-type- and species-specific features, by the ability of nuclear architecture to adapt to specific environmental demands, as well as by the impact of aberrant nuclear organization on senescence and human disease. We conclude this chapter with a reflection on the necessity of interdisciplinary research strategies to map epigenomes in space and time. |
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Authors:
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Jan Postberg; Hans J Lipps; Thomas Cremer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Essays in biochemistry Volume: 48 ISSN: 1744-1358 ISO Abbreviation: Essays Biochem. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-08 Completed Date: 2010-12-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0043306 Medline TA: Essays Biochem Country: England |
Other Details:
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Languages: eng Pagination: 1-24 Citation Subset: IM |
Affiliation:
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University of Witten/Herdecke, Center for Biomedical Education and Research (ZBAF), Institute of Cell Biology, Witten, Germany. jan.postberg@uni-wh.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Evolution* Cell Nucleus* DNA Replication Transcription, Genetic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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