Document Detail

Evolutionary origin of the cell nucleus and its functional architecture.
MedLine Citation:
PMID:  20822483     Owner:  NLM     Status:  MEDLINE    
Understanding the evolutionary origin of the nucleus and its compartmentalized architecture provides a huge but, as expected, greatly rewarding challenge in the post-genomic era. We start this chapter with a survey of current hypotheses on the evolutionary origin of the cell nucleus. Thereafter, we provide an overview of evolutionarily conserved features of chromatin organization and arrangements, as well as topographical aspects of DNA replication and transcription, followed by a brief introduction of current models of nuclear architecture. In addition to features which may possibly apply to all eukaryotes, the evolutionary plasticity of higher-order nuclear organization is reflected by cell-type- and species-specific features, by the ability of nuclear architecture to adapt to specific environmental demands, as well as by the impact of aberrant nuclear organization on senescence and human disease. We conclude this chapter with a reflection on the necessity of interdisciplinary research strategies to map epigenomes in space and time.
Jan Postberg; Hans J Lipps; Thomas Cremer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Essays in biochemistry     Volume:  48     ISSN:  1744-1358     ISO Abbreviation:  Essays Biochem.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-08     Completed Date:  2010-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0043306     Medline TA:  Essays Biochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-24     Citation Subset:  IM    
University of Witten/Herdecke, Center for Biomedical Education and Research (ZBAF), Institute of Cell Biology, Witten, Germany.
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MeSH Terms
Biological Evolution*
Cell Nucleus*
DNA Replication
Transcription, Genetic

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