Document Detail

Evolutionary game theoretic strategy for optimal drug delivery to influence selection pressure in treatment of HIV-1.
MedLine Citation:
PMID:  21503727     Owner:  NLM     Status:  Publisher    
Cytotoxic T-lymphocyte (CTL) escape mutation is associated with long-term behaviors of human immunodeficiency virus type 1 (HIV-1). Recent studies indicate heterogeneous behaviors of reversible and conservative mutants while the selection pressure changes. The purpose of this study is to optimize the selection pressure to minimize the long-term virus load. The results can be used to assist in delivery of highly loaded cognate peptide-pulsed dendritic cells (DC) into lymph nodes that could change the selection pressure. This mechanism may be employed for controlled drug delivery. A mathematical model is proposed in this paper to describe the evolutionary dynamics involving viruses and T cells. We formulate the optimization problem into the framework of evolutionary game theory, and solve for the optimal control of the selection pressure as a neighborhood invader strategy. The strategy dynamics can be obtained to evolve the immune system to the best controlled state. The study may shed light on optimal design of HIV-1 therapy based on optimization of adaptive CTL immune response.
Yu Wu; Mingjun Zhang; Jing Wu; Xiaopeng Zhao; Lijin Xia
Related Documents :
21144107 - A possible role of plasma aldosterone in hypotension secondary to iron-deficiency anaem...
25260007 - Volumetric deformation of live cells induced by pressure-activated cross-membrane ion t...
21461927 - Distensibility in human veins as affected by 5 weeks of repeated elevations of local t...
21526127 - Smooth muscle mirnas are critical for post-natal regulation of blood pressure and vascu...
1621497 - Variations of homovanillic acid levels in ventricular cerebrospinal fluid.
1002397 - Urethral pressure profile measurements in children.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-19
Journal Detail:
Title:  Journal of mathematical biology     Volume:  -     ISSN:  1432-1416     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7502105     Medline TA:  J Math Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Mechanical, Aerospace and Biomedical Engineering Department, University of Tennessee, Knoxville, TN, 37996, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hormetins, antioxidants and prooxidants: defining quercetin-, caffeic acid- and rosmarinic acid-medi...
Next Document:  Simulation of lamellipodial fragments.