| Evolutionary clues to the functions of the Toll-like family as surveillance receptors. | |
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MedLine Citation:
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PMID: 12495720 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The origin of the Toll-like family of receptors pre-dates the evolutionary split between the plant and animal kingdoms. These receptors are remarkably conserved across the taxonomic kingdoms and have fundamental roles in triggering immune responses. How they trigger such responses, and how these mechanisms arose in evolution, is a topic of extensive debate. We postulate a surveillance model: these receptors "keep watch" for both endogenous and exogenous molecules that indicate tissue injury, infection and remodeling. Furthermore, we suggest that the first Toll-like family receptors that arose in evolution might have acted in both development and immunity by recognizing the degradation of endogenous macromolecules. |
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Authors:
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Geoffrey B Johnson; Gregory J Brunn; Amy H Tang; Jeffrey L Platt |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Trends in immunology Volume: 24 ISSN: 1471-4906 ISO Abbreviation: Trends Immunol. Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2002-12-23 Completed Date: 2004-01-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100966032 Medline TA: Trends Immunol Country: England |
Other Details:
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Languages: eng Pagination: 19-24 Citation Subset: IM |
Affiliation:
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Department of Immunology, 2-66 Medical Sciences Building, Mayo Clinic, Rochester, MN 55905, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Evolution, Molecular* Humans Immunologic Surveillance / immunology* Membrane Glycoproteins / genetics, immunology, metabolism* Models, Biological Polysaccharides / immunology, metabolism Proteoglycans / metabolism Receptors, Cell Surface / genetics, immunology, metabolism* Toll-Like Receptors |
| Grant Support | |
ID/Acronym/Agency:
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AI 53733/AI/NIAID NIH HHS; HL 46810/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Membrane Glycoproteins; 0/Polysaccharides; 0/Proteoglycans; 0/Receptors, Cell Surface; 0/Toll-Like Receptors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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