Document Detail


Evolutionary breakpoints on human chromosome 21.
MedLine Citation:
PMID:  11707078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Segments of the long arm of human chromosome 21 are conserved, centromere to telomere, in mouse chromosomes 16, 17, and 10. There have been 28 genes identified in human chromosome 21 between TMPRSS2, whose orthologue is the most distal gene mapped to mouse chromosome 16, and PDXK, whose orthologue is the most proximal gene mapped to mouse chromosome 10. Only 6 of these 28 genes have been mapped in mouse, and all are located on chromosome 17. To better define the chromosome 17 segment and the 16 to 17 transition, we used a combination of mouse radiation hybrid panel mapping and physical mapping by mouse: human genomic sequence comparison. We have determined the mouse chromosomal location of an additional 12 genes, predicted the location of 7 more,and defined the endpoints of the mouse chromosome 17 region. The mouse chromosome 16/chromosome 17 evolutionary breakpoint is between human genes ZNF295 and UMODL1, showing there are seven genes in the chromosome 16 segment distal to Tmprss2. The chromosome 17/chromosome 10 breakpoint seems to have involved a duplication of the gene PDXK, which on chromosome 21 lies immediately distal to the KIAA0179 gene. These data suggest that there may be as few as 21 functional genes in the mouse chromosome 17 segment. This information is important for defining existing and constructing more complete mouse models of Down syndrome.
Authors:
M T Davisson; L J Bechtel; E C Akeson; A Fortna; D Slavov; K Gardiner
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  78     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-14     Completed Date:  2002-01-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  99-106     Citation Subset:  IM    
Affiliation:
The Jackson Laboratory, Bar Harbor, Maine 04609, USA. mtd@jax.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromosome Mapping
Chromosomes / genetics
Chromosomes, Human, Pair 21 / genetics*
Cricetinae
Evolution, Molecular*
Humans
Hybrid Cells
In Situ Hybridization, Fluorescence
Mice
Radiation Hybrid Mapping
Synteny
Grant Support
ID/Acronym/Agency:
CA34196/CA/NCI NIH HHS; N01 HD73265/HD/NICHD NIH HHS; P01 HD17449/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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