| The Evolutionary Role of the IL-33/ST2 System in Host Immune Defence. | |
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MedLine Citation:
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PMID: 23283516 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Interleukin (IL)-33 is a recently identified pleiotropic cytokine, which can orchestrate complex innate and adaptive immune responses in immunity and disease. It has been characterized as a cytokine of the IL-1 family and affects a wide range of immune cells by signalling through its receptor ST2L. Accumulating evidence suggests a crucial role of IL-33/ST2 in inducing and modifying host immune responses against a variety of pathogens including parasites, bacteria, viruses and fungi as well as sterile insults of both endogenous and exogenous source. In this review, we endeavour to give a comprehensive overview of the current knowledge about the role of IL-33 and its receptor ST2 in host defence against infections. |
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Authors:
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Susanne Sattler; Hermelijn H Smits; Damo Xu; Fang-Ping Huang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-3 |
Journal Detail:
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Title: Archivum immunologiae et therapiae experimentalis Volume: - ISSN: 1661-4917 ISO Abbreviation: Arch. Immunol. Ther. Exp. (Warsz.) Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0114365 Medline TA: Arch Immunol Ther Exp (Warsz) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Medicine, Centre for Complement and Inflammation Research, Imperial College London, Hammersmith Campus, Du Cane Road, W12 0NN, London, UK, s.sattler@imperial.ac.uk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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