Document Detail

The Evolutionary Role of the IL-33/ST2 System in Host Immune Defence.
MedLine Citation:
PMID:  23283516     Owner:  NLM     Status:  Publisher    
Interleukin (IL)-33 is a recently identified pleiotropic cytokine, which can orchestrate complex innate and adaptive immune responses in immunity and disease. It has been characterized as a cytokine of the IL-1 family and affects a wide range of immune cells by signalling through its receptor ST2L. Accumulating evidence suggests a crucial role of IL-33/ST2 in inducing and modifying host immune responses against a variety of pathogens including parasites, bacteria, viruses and fungi as well as sterile insults of both endogenous and exogenous source. In this review, we endeavour to give a comprehensive overview of the current knowledge about the role of IL-33 and its receptor ST2 in host defence against infections.
Susanne Sattler; Hermelijn H Smits; Damo Xu; Fang-Ping Huang
Related Documents :
24667956 - Managing cytokine release syndrome associated with novel t cell-engaging therapies.
24442036 - Immune resistance and tolerance to fungi.
23308256 - Functional characterization of domains of ips-1 using an inducible oligomerization system.
23601906 - Cd39 and cd73 in immunity and inflammation.
17407366 - Immunomodulatory effects of macrolide antibiotics in respiratory disease: therapeutic i...
16751406 - C-reactive protein increases cytokine responses to streptococcus pneumoniae through int...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-3
Journal Detail:
Title:  Archivum immunologiae et therapiae experimentalis     Volume:  -     ISSN:  1661-4917     ISO Abbreviation:  Arch. Immunol. Ther. Exp. (Warsz.)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0114365     Medline TA:  Arch Immunol Ther Exp (Warsz)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Medicine, Centre for Complement and Inflammation Research, Imperial College London, Hammersmith Campus, Du Cane Road, W12 0NN, London, UK,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Genome-wide identification of laccase gene family in three Phytophthora species.
Next Document:  Brain-Derived Neurotrophic Factor in Neuroimmunology: Lessons Learned from Multiple Sclerosis Patien...